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. 1986 Apr 16;371(1):146-51.
doi: 10.1016/0006-8993(86)90819-x.

Nicotinic acetylcholine binding sites in Alzheimer's disease

P J Whitehouse, A M Martino, P G Antuono, P R Lowenstein, J T Coyle, D L Price, K J Kellar

Nicotinic acetylcholine binding sites in Alzheimer's disease

P J Whitehouse et al. Brain Res. .

Abstract

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.

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