Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus

doi:10.1007/s11926-023-01102-z

Review

. 2023 Jun;25(6):107-116.

doi: 10.1007/s11926-023-01102-z. Epub 2023 Apr 21.

Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus

Yu Lei^#^{1

2

3

4}, Qianmei Liu^#^{1

2

3}, Qilin Li^{1

2

3

4}, Cheng Zhao^{1

2

3

4}, Ming Zhao^#^{5

6

7

8}, Qianjin Lu^#^{9

10

11

12}

Affiliations

¹ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
² Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China.
³ Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China.
⁴ Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China.
⁵ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China. zhaoming301@pumcderm.cams.cn.
⁶ Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China. zhaoming301@pumcderm.cams.cn.
⁷ Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China. zhaoming301@pumcderm.cams.cn.
⁸ Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China. zhaoming301@pumcderm.cams.cn.
⁹ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China. qianlu5860@pumcderm.cams.cn.
¹⁰ Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China. qianlu5860@pumcderm.cams.cn.
¹¹ Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China. qianlu5860@pumcderm.cams.cn.
¹² Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China. qianlu5860@pumcderm.cams.cn.

^# Contributed equally.

PMID: 37083877
DOI: 10.1007/s11926-023-01102-z

Review

Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus

Yu Lei et al. Curr Rheumatol Rep. 2023 Jun.

. 2023 Jun;25(6):107-116.

doi: 10.1007/s11926-023-01102-z. Epub 2023 Apr 21.

Authors

Yu Lei^#^{1

2

3

4}, Qianmei Liu^#^{1

2

3}, Qilin Li^{1

2

3

4}, Cheng Zhao^{1

2

3

4}, Ming Zhao^#^{5

6

7

8}, Qianjin Lu^#^{9

10

11

12}

Affiliations

¹ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
² Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China.
³ Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China.
⁴ Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China.
⁵ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China. zhaoming301@pumcderm.cams.cn.
⁶ Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China. zhaoming301@pumcderm.cams.cn.
⁷ Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China. zhaoming301@pumcderm.cams.cn.
⁸ Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China. zhaoming301@pumcderm.cams.cn.
⁹ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China. qianlu5860@pumcderm.cams.cn.
¹⁰ Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China. qianlu5860@pumcderm.cams.cn.
¹¹ Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China. qianlu5860@pumcderm.cams.cn.
¹² Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China. qianlu5860@pumcderm.cams.cn.

^# Contributed equally.

PMID: 37083877
DOI: 10.1007/s11926-023-01102-z

Abstract

Purpose of review: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by various autoantibodies and multi-organ. Microbiota dysbiosis in the gut, skin, oral, and other surfaces has a significant impact on SLE development. This article summarizes relevant research and provides new microbiome-related strategies for exploring the mechanisms and treating patients with SLE.

Recent findings: SLE patients have disruptions in multiple microbiomes, with the gut microbiota (bacteria, viruses, and fungi) and their metabolites being the most thoroughly researched. This dysbiosis can promote SLE progression through mechanisms such as the leaky gut, molecular mimicry, and epigenetic regulation. Notwithstanding study constraints on the relationship between microbiota and SLE, specific interventions targeting the gut microbiota, such as probiotics, dietary management, and fecal microbiota transplantation, have emerged as promising SLE therapeutics.

Keywords: Autoimmunity; Dysbiosis; Microbiota; Systemic lupus erythematosus.

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Chasov V, Zmievskaya E, Ganeeva I, Gilyazova E, Davletshin D, Filimonova M, Valiullina A, Kudriaeva A, Bulatov E. Chasov V, et al. J Biomed Res. 2024 May 31;38(6):531-546. doi: 10.7555/JBR.38.20240009. J Biomed Res. 2024. PMID: 38828853 Free PMC article.
The Complex Role of Gut Microbiota in Systemic Lupus Erythematosus and Lupus Nephritis: From Pathogenetic Factor to Therapeutic Target.
Parodi E, Novi M, Bottino P, La Porta E, Merlotti G, Castello LM, Gotta F, Rocchetti A, Quaglia M. Parodi E, et al. Microorganisms. 2025 Feb 18;13(2):445. doi: 10.3390/microorganisms13020445. Microorganisms. 2025. PMID: 40005809 Free PMC article. Review.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

1. Dominguez-Bello MG, Godoy-Vitorino F, Knight R, Blaser MJ. Role of the microbiome in human development. Gut. 2019;68(6):1108–14. https://doi.org/10.1136/gutjnl-2018-317503 . - DOI - PubMed
1. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207–14. https://doi.org/10.1038/nature11234 .
1. Kishikawa T, Maeda Y, Nii T, Motooka D, Matsumoto Y, Matsushita M, et al. Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population. Ann Rheum Dis. 2020;79(1):103–11. https://doi.org/10.1136/annrheumdis-2019-215743 . - DOI - PubMed
1. Chen BD, Jia XM, Xu JY, Zhao LD, Ji JY, Wu BX, et al. An autoimmunogenic and proinflammatory profile defined by the gut microbiota of patients with untreated systemic lupus erythematosus. Arthritis Rheumatology (Hoboken, NJ). 2021;73(2):232–43. https://doi.org/10.1002/art.41511 . - DOI
1. Kishikawa T, Ogawa K, Motooka D, Hosokawa A, Kinoshita M, Suzuki K, et al. A metagenome-wide association study of gut microbiome in patients with multiple sclerosis revealed novel disease pathology. Front Cell Infect Microbiol. 2020;10:585973. https://doi.org/10.3389/fcimb.2020.585973 . - DOI - PubMed - PMC

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[1] Dominguez-Bello MG, Godoy-Vitorino F, Knight R, Blaser MJ. Role of the microbiome in human development. Gut. 2019;68(6):1108–14. https://doi.org/10.1136/gutjnl-2018-317503 . - DOI - PubMed

[2] Dominguez-Bello MG, Godoy-Vitorino F, Knight R, Blaser MJ. Role of the microbiome in human development. Gut. 2019;68(6):1108–14. https://doi.org/10.1136/gutjnl-2018-317503 . - DOI - PubMed

[3] Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207–14. https://doi.org/10.1038/nature11234 .

[4] Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207–14. https://doi.org/10.1038/nature11234 .

[5] Kishikawa T, Maeda Y, Nii T, Motooka D, Matsumoto Y, Matsushita M, et al. Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population. Ann Rheum Dis. 2020;79(1):103–11. https://doi.org/10.1136/annrheumdis-2019-215743 . - DOI - PubMed

[6] Kishikawa T, Maeda Y, Nii T, Motooka D, Matsumoto Y, Matsushita M, et al. Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population. Ann Rheum Dis. 2020;79(1):103–11. https://doi.org/10.1136/annrheumdis-2019-215743 . - DOI - PubMed

[7] Chen BD, Jia XM, Xu JY, Zhao LD, Ji JY, Wu BX, et al. An autoimmunogenic and proinflammatory profile defined by the gut microbiota of patients with untreated systemic lupus erythematosus. Arthritis Rheumatology (Hoboken, NJ). 2021;73(2):232–43. https://doi.org/10.1002/art.41511 . - DOI

[8] Chen BD, Jia XM, Xu JY, Zhao LD, Ji JY, Wu BX, et al. An autoimmunogenic and proinflammatory profile defined by the gut microbiota of patients with untreated systemic lupus erythematosus. Arthritis Rheumatology (Hoboken, NJ). 2021;73(2):232–43. https://doi.org/10.1002/art.41511 . - DOI

[9] Kishikawa T, Ogawa K, Motooka D, Hosokawa A, Kinoshita M, Suzuki K, et al. A metagenome-wide association study of gut microbiome in patients with multiple sclerosis revealed novel disease pathology. Front Cell Infect Microbiol. 2020;10:585973. https://doi.org/10.3389/fcimb.2020.585973 . - DOI - PubMed - PMC

[10] Kishikawa T, Ogawa K, Motooka D, Hosokawa A, Kinoshita M, Suzuki K, et al. A metagenome-wide association study of gut microbiome in patients with multiple sclerosis revealed novel disease pathology. Front Cell Infect Microbiol. 2020;10:585973. https://doi.org/10.3389/fcimb.2020.585973 . - DOI - PubMed - PMC

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Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus

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Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus

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