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. 2023 Jun;12(11):12118-12127.
doi: 10.1002/cam4.5901. Epub 2023 Apr 21.

Variations in colorectal cancer pattern of care by age and comorbidity in South Australia

Kazzem Gheybi  1   2   3 , Elizabeth Buckley  1 , Agnes Vitry  4 , David Roder  1   2
Affiliations

Variations in colorectal cancer pattern of care by age and comorbidity in South Australia

Kazzem Gheybi et al. Cancer Med. 2023 Jun.

Abstract

Background: Advanced age is associated with decreased likelihood of colorectal cancer treatment. Here, we investigated the extent to which comorbidities are accountable for this lesser treatment.

Methods: Using population-based datasets, the pattern of care among CRC cases in South Australia during 2004-2013 was investigated. Models were used to investigate associations of age with each treatment type, and differences in these associations were explored by comorbidity and cancer site.

Results: The presence of comorbidity was associated with a significantly weaker relationship of age with surgery and chemotherapy. The association of age with surgery also varied for colon and rectal primary cancer sites. Individual comorbidity types varied in their associations with each treatment category. For example, dementia was associated with less chemotherapy provision, however, it was not significantly related to the likelihood of surgery.

Conclusion: This study indicates that the association of age with surgical treatment differed significantly by the CRC subsite. Comorbidity moderated the negative association of age with chemotherapy, and less so, with extent of surgery. Results were novel in indicating associations of multiple individual comorbidity types with CRC treatment modalities. The data suggest that different individual comorbidity types may have different effects on treatment and should be studied separately.

Keywords: advanced age; chemotherapy; comorbidity; surgery; treatment variation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential competing interest.

Figures

FIGURE 1
FIGURE 1
Association of comorbidities included in the CCI with surgery (green) and chemotherapy (purple), as indicated by logistic regression; CRC cases, South Australia 2004–2013. Note: Results adjusted for age, socioeconomic status, remoteness, primary cancer site, sex, stage, grade, and diagnostic period.
See this image and copyright information in PMC

References

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    1. Gheybi K, Buckley E, Vitry A, Roder D. Associations of advanced age with comorbidity, stage and primary subsite as contributors to mortality from colorectal cancer. Front Public Health. 2023;11:1101771. - PMC - PubMed

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