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Multicenter Study
. 2023 Jul;45(7):1643-1653.
doi: 10.1002/hed.27376. Epub 2023 Apr 21.

Major and minor salivary gland cancers: A multicenter retrospective study

Muhammet Bekir Hacioglu  1 , Bulent Erdogan  1 , Murat Bardakcı  2 , Efnan Algın  2 , Burcu Gulbagcı  3 , Ilhan Hacibekiroglu  3 , Jamshid Hamdard  4 , Omer Fatih Olmez  4 , Hadi Akkus  5 , Berna Oksuzoglu  5 , Sema Sezgin Goksu  6 , Shute Ailia Dae  7 , Ahmet Taner Sumbul  7 , Muzaffer Ugraklı  8 , Mustafa Karaagac  8 , Elif Sahin  9 , Devrim Cabuk  9 , Ozden Ozer  10 , Tugba Yavuzsen  10 , Rukiye Arıkan  11 , Osman Köstek  11 , Muhammed Mustafa Atcı  12 , Abdullah Sakin  12 , Adem Deligonul  13 , Duygu Bayır  14 , Murat Dincer  14 , Oktay Unsal  15 , Ozan Yazıcı  15 , Esra Zeynelgil  16 , Ahmet Gulmez  17 , Hakan Harputluoglu  17 , Cihan Erol  18 , Mehmet Ali Nahit Sendur  18 , Aydin Aytekin  19 , Baran Akagunduz  20 , Irem Oner  21 , Ozlem Er  22 , Bugra Oztosun  23 , Mahmut Gumus  23 , Fatih Selçukbiricik  24 , Musa Baris Aykan  25 , Nuri Karadurmus  25 , Ezgi Degerli  26 , Nebi Serkan Demirci  26 , Esma Turkmen  27 , Teoman Şakalar  28 , Saban Secmeler  29 , Ozgur Tanrıverdi  30 , Ali Alkan  30 , Yasemin Kemal  31 , Ibrahim Cil  32 , Caglar Unal  33 , Yakup Iriagaç  34 , Ozkan Alan  35 , Sevinc Balli  36 , Yuksel Urun  36 , Erkan Ozcan  1 , Nazım Serdar Turhal  37 , Irfan Cicin  1
Affiliations
Multicenter Study

Major and minor salivary gland cancers: A multicenter retrospective study

Muhammet Bekir Hacioglu et al. Head Neck. 2023 Jul.

Abstract

Background: Most of the studies on salivary gland cancers are limited for various reasons such as being single-center, small number of patients, including only major or minor SGCs, or only including epidemiological data.

Methods: A total of 37 medical oncology clinics from different regions of Turkey participated in this retrospective-multicenter study. The analyzed data included clinical and demographical features, primary treatment, metastasis localizations, and treatments and includes certain pathologic features.

Results: The study included data from a total of 443 SGCs. 56.7% was in major salivary glands and 43.3% was in minor salivary glands. Distant metastasis in the major SGCs was statistically significantly more common than in the minor SGCs, locoregional recurrence was statistically significantly more common in the minor SGCs than in the major SGCs (p = 0.003).

Conclusions: Epidemiological information, metastasis and recurrence patterns, treatment modalities, and survival analysis of the patients over 20 years of follow-up are presented.

Keywords: histopathology; incidence; major salivary gland; minor salivary gland; salivary gland cancers.

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