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Comment
. 2023 Apr 20;83(8):1208-1209.
doi: 10.1016/j.molcel.2023.03.019.

NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4

Ilse Delint-Ramirez  1 , Ram Madabhushi  2
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Free article
Comment

NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4

Ilse Delint-Ramirez et al. Mol Cell. .
Free article

Abstract

In a recent study, Pollina et al.1 discover a new neuron-specific NuA4-TIP60 chromatin remodeling complex that facilitates the repair of activity-induced DNA double-strand breaks (DSBs) in neurons and protects against mutations that accumulate with age and early death.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • A NPAS4-NuA4 complex couples synaptic activity to DNA repair.
    Pollina EA, Gilliam DT, Landau AT, Lin C, Pajarillo N, Davis CP, Harmin DA, Yap EL, Vogel IR, Griffith EC, Nagy MA, Ling E, Duffy EE, Sabatini BL, Weitz CJ, Greenberg ME. Pollina EA, et al. Nature. 2023 Feb;614(7949):732-741. doi: 10.1038/s41586-023-05711-7. Epub 2023 Feb 15. Nature. 2023. PMID: 36792830 Free PMC article.

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