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Comment
. 2023 Apr 20;30(4):337-339.
doi: 10.1016/j.chembiol.2023.04.001.

Degrading the signal amplifier: ITK as a target for targeted protein degradation

Avery August  1
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Degrading the signal amplifier: ITK as a target for targeted protein degradation

Avery August. Cell Chem Biol. .
Free article

Abstract

In this issue of Cell Chemical Biology, Jiang and colleagues show for the first time that the Tec kinase ITK can be targeted using PROTAC approaches. This new modality has implications for the treatment of T cell lymphomas, but also potentially for the treatment of T cell-mediated inflammatory diseases, that depend on ITK signaling.

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Conflict of interest statement

Declaration of interests A.A. receives research support from 3M Corporation and has received consultation fees from Pfizer.

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