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Comment
. 2023 Apr 20;30(4):340-342.
doi: 10.1016/j.chembiol.2023.04.002.

A new avenue for molecular glues: Rapid discovery of a NFKB1 degrader

Angela T Fan  1 , Bridget T Boyle  1 , Fleur M Ferguson  2
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A new avenue for molecular glues: Rapid discovery of a NFKB1 degrader

Angela T Fan et al. Cell Chem Biol. .
Free article

Abstract

Targeted protein degradation using molecular glues is a powerful method for targeting traditionally undruggable proteins. One challenge in molecular glue discovery is the absence of rational discovery methods. Here, King et al. leverage covalent library screening with chemoproteomics platforms to rapidly discover a molecular glue targeting NFKB1 via UBE2D recruitment.

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Conflict of interest statement

Declaration of interests FMF is a scientific co-founder and equity holder in Proximity Therapeutics and a scientific advisory board member and equity holder in Triana Biomedicines. Fleur Ferguson is or was recently a consultant or received speaking honoraria from Eli Lilly and Co., RA Capital, Tocris BioTechne, and Plexium Inc. The Ferguson lab receives or has received research funding from Ono Pharmaceutical Co. Ltd and Merck & Co.

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