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Comment
. 2023 May 16;4(5):101021.
doi: 10.1016/j.xcrm.2023.101021. Epub 2023 Apr 20.

Use of a multi-gene pharmacogenetic panel reduces adverse drug effects

Larisa H Cavallari  1 , Julie A Johnson  2
Affiliations
Comment

Use of a multi-gene pharmacogenetic panel reduces adverse drug effects

Larisa H Cavallari et al. Cell Rep Med. .

Abstract

Swen et al.1 examine the utility of multi-gene pharmacogenetic testing in a large multi-national cohort. They show fewer adverse drug reactions among patients receiving testing and prescribing recommendations based on genotype results compared with those receiving usual care.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study.
    Swen JJ, van der Wouden CH, Manson LE, Abdullah-Koolmees H, Blagec K, Blagus T, Böhringer S, Cambon-Thomsen A, Cecchin E, Cheung KC, Deneer VH, Dupui M, Ingelman-Sundberg M, Jonsson S, Joefield-Roka C, Just KS, Karlsson MO, Konta L, Koopmann R, Kriek M, Lehr T, Mitropoulou C, Rial-Sebbag E, Rollinson V, Roncato R, Samwald M, Schaeffeler E, Skokou M, Schwab M, Steinberger D, Stingl JC, Tremmel R, Turner RM, van Rhenen MH, Dávila Fajardo CL, Dolžan V, Patrinos GP, Pirmohamed M, Sunder-Plassmann G, Toffoli G, Guchelaar HJ; Ubiquitous Pharmacogenomics Consortium. Swen JJ, et al. Lancet. 2023 Feb 4;401(10374):347-356. doi: 10.1016/S0140-6736(22)01841-4. Lancet. 2023. PMID: 36739136 Clinical Trial.

References

    1. Swen J.J., van der Wouden C.H., Manson L.E., Abdullah-Koolmees H., Blagec K., Blagus T., Bohringer S., Cambon-Thomsen A., Cecchin E., Cheung K.C., et al. Ubiquitous Pharmacogenomics Consortium A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet. 2023;401:347–356. - PubMed
    1. Roden D.M., McLeod H.L., Relling M.V., Williams M.S., Mensah G.A., Peterson J.F., Van Driest S.L. Pharmacogenomics. Lancet. 2019;394:521–532. - PMC - PubMed
    1. Implementation. https://cpicpgx.org/implementation/. Accessed March 5, 2023.
    1. Relling M.V., Klein T.E. CPIC: clinical pharmacogenetics implementation Consortium of the Pharmacogenomics Research Network. Clin. Pharmacol. Ther. 2011;89:464–467. - PMC - PubMed
    1. Swen J.J., Nijenhuis M., de Boer A., Grandia L., Maitland-van der Zee A.H., Mulder H., Rongen G.A.P.J.M., van Schaik R.H.N., Schalekamp T., Touw D.J., et al. Pharmacogenetics: from bench to byte--an update of guidelines. Clin. Pharmacol. Ther. 2011;89:662–673. - PubMed

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