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Review
. 2023 Jun;44(2):249-262.
doi: 10.1016/j.ccm.2022.11.011. Epub 2022 Nov 23.

Impact of COVID-19 on Nonpulmonary Critical Illness: Prevalence, Clinical Manifestations, Management, and Outcomes

Mina Pirzadeh  1 , Hallie C Prescott  2
Affiliations
Review

Impact of COVID-19 on Nonpulmonary Critical Illness: Prevalence, Clinical Manifestations, Management, and Outcomes

Mina Pirzadeh et al. Clin Chest Med. 2023 Jun.

Abstract

Although respiratory manifestations are the most common driver of hospitalization, SARS-CoV-2 infection has a wide range of manifestations, including multisystem organ failure in severe cases. This review discusses the prevalence, pathophysiology, clinical manifestations, treatment, and outcomes of nonpulmonary organ dysfunction from SARS-CoV2, including renal, liver, cardiac, neurologic, and coagulation system dysfunction. At this time, management largely focuses on supportive care practices that are applicable regardless of the cause of organ injury.

Keywords: COVID-19; Critical illness; Organ failure; Sepsis.

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Figures

Fig. 1
Fig. 1
Nonpulmonary critical organ dysfunctions due to COVID-19 infection.
Fig. 2
Fig. 2
Endotheliopathy in COVID-19 coagulopathy.
See this image and copyright information in PMC

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