Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun;44(2):249-262.
doi: 10.1016/j.ccm.2022.11.011. Epub 2022 Nov 23.

Impact of COVID-19 on Nonpulmonary Critical Illness: Prevalence, Clinical Manifestations, Management, and Outcomes

Mina Pirzadeh  1 , Hallie C Prescott  2
Affiliations
Review

Impact of COVID-19 on Nonpulmonary Critical Illness: Prevalence, Clinical Manifestations, Management, and Outcomes

Mina Pirzadeh et al. Clin Chest Med. 2023 Jun.

Abstract

Although respiratory manifestations are the most common driver of hospitalization, SARS-CoV-2 infection has a wide range of manifestations, including multisystem organ failure in severe cases. This review discusses the prevalence, pathophysiology, clinical manifestations, treatment, and outcomes of nonpulmonary organ dysfunction from SARS-CoV2, including renal, liver, cardiac, neurologic, and coagulation system dysfunction. At this time, management largely focuses on supportive care practices that are applicable regardless of the cause of organ injury.

Keywords: COVID-19; Critical illness; Organ failure; Sepsis.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Nonpulmonary critical organ dysfunctions due to COVID-19 infection.
Fig. 2
Fig. 2
Endotheliopathy in COVID-19 coagulopathy.
See this image and copyright information in PMC

References

    1. Coronavirus World Map: tracking the global outbreak. the New York times. https://www.nytimes.com/interactive/2021/world/covid-cases.html?smid=url... Available at: Updated May 1, 2022. Accessed May 1, 2022, 2022.
    1. Karakike E., Giamarellos-Bourboulis E.J., Kyprianou M., et al. Coronavirus disease 2019 as cause of viral sepsis: a systematic review and meta-analysis. Crit Care Med. 2021;49(12):2042–2057. - PMC - PubMed
    1. Shappell C.N., Klompas M., Rhee C. Quantifying the burden of viral sepsis during the coronavirus disease 2019 pandemic and beyond. Crit Care Med. 2021;49(12):2140–2143. - PMC - PubMed
    1. Lopes-Pacheco M., Silva P.L., Cruz F.F., et al. Pathogenesis of multiple organ injury in covid-19 and potential therapeutic strategies. review. Front Physiol. 2021;12 doi: 10.3389/fphys.2021.593223. - DOI - PMC - PubMed
    1. Domecq J.P., Lal A., Sheldrick C.R., et al. Outcomes of patients with coronavirus disease 2019 receiving organ support therapies: the international viral infection and respiratory illness universal study registry. Crit Care Med. 2021;49(3):437–448. - PMC - PubMed

Publication types