Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun;44(2):395-406.
doi: 10.1016/j.ccm.2022.11.012. Epub 2022 Nov 22.

Coronavirus Disease-2019 in the Immunocompromised Host

Christopher D Bertini Jr  1 , Fareed Khawaja  2 , Ajay Sheshadri  3
Affiliations
Review

Coronavirus Disease-2019 in the Immunocompromised Host

Christopher D Bertini Jr et al. Clin Chest Med. 2023 Jun.

Abstract

Immunocompromised hosts, which encompass a diverse population of persons with malignancies, human immunodeficiency virus disease, solid organ, and hematologic transplants, autoimmune diseases, and primary immunodeficiencies, bear a significant burden of the morbidity and mortality due to coronavirus disease-2019 (COVID-19). Immunocompromised patients who develop COVID-19 have a more severe illness, higher hospitalization rates, and higher mortality rates than immunocompetent patients. There are no well-defined treatment strategies that are specific to immunocompromised patients and vaccines, monoclonal antibodies, and convalescent plasma are variably effective. This review focuses on the specific impact of COVID-19 in immunocompromised patients and the gaps in knowledge that require further study.

Keywords: COVID-19; Hematologic malignancy; Immunocompromised host; Immunosuppression; Pneumonia; SARS-CoV-2.

PubMed Disclaimer

References

    1. WHO. WHO Coronavirus disease (COVID-19) dashboard In:2022. Available at: https://covid19.who.int/
    1. Kim Y., Waghmare A., Xie H., et al. Respiratory viruses in hematopoietic cell transplant candidates: impact of preexisting lower tract disease on outcomes. Blood Adv. 2022;6:5307–5316. - PMC - PubMed
    1. Raje N., Dinakar C. Overview of immunodeficiency disorders. Immunol Allergy Clin N Am. 2015;35(4):599–623. - PMC - PubMed
    1. Chinen J., Shearer W.T. Secondary immunodeficiencies, including HIV infection. J Allergy Clin Immunol. 2010;125(2):S195–S203. - PMC - PubMed
    1. Mahamat-Saleh Y., Fiolet T., Rebeaud M.E., et al. Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: a systematic review and meta-analysis of observational studies. BMJ Open. 2021;11(10):e052777. - PMC - PubMed