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. 2023 Apr 21;13(1):6521.
doi: 10.1038/s41598-023-32292-2.

Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran

Seyedeh Mahideh Namayandeh  1 , HamidReza Dehghan  2 , Mohammad Hassan Lotfi  3 , Mohammad Reza Khajehaminian  4 , Saeed Hosseini  3 , Vali Bahrevar  5 , AliAkbar Jarrahi  6 , Fatemeh Majidpour  7
Affiliations

Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran

Seyedeh Mahideh Namayandeh et al. Sci Rep. .

Abstract

This study was designed and implemented to analyze and establish documents related to the above cases in the first to third COVID-19 epidemic waves for the use of researchers and doctors during and after the epidemic. The current case series study was conducted on 24,563 thousand hospitalized COVID-19 patients by examining their clinical characteristics within a one-year period from the beginning of the pandemic on 02.22.2020 to 02.14.2021, which included the first to the third waves, based on gender and severity of COVID-19. The mean age of the participants was 56 ± 20.71, and 51.8% were male. Out of a total of 24,563 thousand hospitalized COVID-19 patients until February 2021, there were 2185 mortalities (9.8%) and 2559 cases of severe COVID-19 (13.1%). The median length of hospitalization from the time of admission to discharge or death in the hospital (IQR: 13-41) was estimated to be 21 days. The rate of hospital mortality was higher in severe (37.8%) than in non-severe (4.8%) cases of COVID-19, While the risk of severe cases increased significantly in the third (HR = 1.65, 95% CI: 1.46-1.87, P < 0.001) and early fourth waves (HR = 2.145, 95% CI: 1.7-2.71, P < 0.001). Also, the risk of contracting severe COVID-19 increased significantly in patients aged ≥ 65 years old (HR = 2.1, 95% CI 1.1.93-2.72, P < 0.001). As shown by the results, the rates of hospital mortality (9.3% vs. 8.5%) and severe cases of COVID-19 (13.6% vs. 12.5%) were higher among men than women (P < 0.01). In our study, the mortality rate and severity of COVID-19 were within the scope of global studies. Men experienced higher severity and mortality than women. The was a significantly higher prevalence of old age and underlying diseases in individuals with severe COVID-19. Our data also showed that patients with a previous history of COVID-19 had a more severe experience of COVID-19, while most of these patients were also significantly older and had an underlying disease.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Map of Iran with location of Yazd Area (Yazd province is shown in Highlight, From Wikipedia, the free encyclopedia, https://en.wikipedia.org/wiki/File:Iran_location_map.svg).
Figure 2
Figure 2
Shows frequency distribution of in-hospital mortality of COVID-19 based to severity disease.
Figure 3
Figure 3
The median length of hospitalization from admission to death/discharge in hospitalized patients' death(Graph A) using the Kaplan-Meir method based on severity(Graph B), age(Graph C), sex(Graph D), pandemic waves(Graph E).
Figure 3
Figure 3
The median length of hospitalization from admission to death/discharge in hospitalized patients' death(Graph A) using the Kaplan-Meir method based on severity(Graph B), age(Graph C), sex(Graph D), pandemic waves(Graph E).
See this image and copyright information in PMC

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