Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr 21;13(1):6589.
doi: 10.1038/s41598-023-33672-4.

Influenza season influence on outcome of new nodules in the NELSON study

H L Lancaster  1 , M A Heuvelmans  1 , G H de Bock  1 , Y Du  1 , F A A Mohamed Hoesein  2 , K Nackaerts  3 , J E Walter  4 , R Vliegenthart  5 , M Oudkerk  6
Affiliations

Influenza season influence on outcome of new nodules in the NELSON study

H L Lancaster et al. Sci Rep. .

Abstract

We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detected per season was calculated and compared. Winter (influenza season) was defined as 1st October to 31st March, and compared to the summer (hay-fever season), 1st April to 30th September. Overall, 820 new nodules were reported in 529 participants. Of the total new nodules, 482 (59%) were reported during winter. When considering the outcome of all new nodules, there was no statistically significant association between summer and resolving nodules (OR 1.07 [CI 1.00-1.15], p = 0.066), also when looking at the largest nodule per participant (OR 1.37 [CI 0.95-1.98], p = 0.094). Similarly, there was no statistically significant association between season and screen detected cancers (OR 0.47 [CI 0.18-1.23], p = 0.123). To conclude, in this lung cancer screening population, there was no statistically significant association between influenza season and outcome of new lung nodules. Hence, we recommend new nodule management strategy is not influenced by the season in which the nodule is detected.

PubMed Disclaimer

Conflict of interest statement

R. Vliegenthart is supported by an institutional research grant from Siemens Healthineers. All other authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Overview of new resolving and persisting (sub)solid lung nodules included in this sub-study of the NELSON trial. *a nodule had no follow up scan when a participant was referred immediately to a pulmonologist for further diagnostics, or the participant did not require an additional CT scan according to protocol.
See this image and copyright information in PMC

References

    1. Balata H, Evison M, Sharman A, Crosbie P, Booton R. CT screening for lung cancer: Are we ready to implement in Europe? Lung Cancer. 2019;134:25–33. doi: 10.1016/j.lungcan.2019.05.028. - DOI - PubMed
    1. The Global Cancer Observatory. All cancers [Internet]. 2020 [cited 2021 Apr 27]. Available from: https://gco.iarc.fr/today
    1. Fitzmaurice C, Akinyemiju TF, Al Lami FH, Alam T, Alizadeh-Navaei R, Allen C, et al. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2018;4(11):1553–1568. doi: 10.1001/jamaoncol.2018.2706. - DOI - PMC - PubMed
    1. Jaklitsch, M. T., Jacobson, F. L., Austin, J. H. M., Field, J. K., Jett, J. R., Keshavjee, S., et al. The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups (2012). Cited 2019 Sept 8. https://com-mendeley-prod-publicsharing-pdfstore.s3.eu-west-1.amazonaws.... - PubMed
    1. Wood DE, Eapen GA, Ettinger DS, Hou L, Jackman D, Kazerooni E, et al. Lung cancer screening. J. Natl. Comp. Cancer Netw. 2012;10(2):240–265. doi: 10.6004/jnccn.2012.0022. - DOI - PMC - PubMed

Publication types