Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul;48(7):2207-2218.
doi: 10.1007/s00261-023-03920-2. Epub 2023 Apr 21.

Application of intravoxel incoherent motion diffusion-weighted imaging for preoperative knowledge of lymphovascular invasion in gastric cancer: a prospective study

Jing Li  1 , Liang-Liang Yan  1 , Hong-Kai Zhang  1 , Yi Wang  2 , Shu-Ning Xu  3 , Xue-Jun Chen  1 , Jin-Rong Qu  4
Affiliations

Application of intravoxel incoherent motion diffusion-weighted imaging for preoperative knowledge of lymphovascular invasion in gastric cancer: a prospective study

Jing Li et al. Abdom Radiol (NY). 2023 Jul.

Abstract

Purpose: To investigate the potential of intravoxel incoherent motion diffusion-weighted imaging (IVIM) for preoperative prediction of lymphovascular invasion (LVI) in gastric cancer (GC).

Methods: This study prospectively enrolled 90 patients (62 males, 28 females, 60.79 ± 9.99 years old) who received radical gastrostomy. Abdominal MRI examinations including IVIM were performed within 1 week before surgery. Patients were divided into LVI-positive and -negative group according to pathological diagnosis after surgery. The apparent diffusion coefficient (ADC) and IVIM parameters, including true diffusion coefficient (D), pseudodiffusion coefficient (D*), and pseudodiffusion fraction (f), were compared between the two groups. The relationship between MRI parameters and LVI was studied by Spearman's correlation analysis. Multivariable logistic regression analysis was used to screen independent predictors of LVI. Receiver-operating characteristic curve analyses were applied to evaluate the efficacy.

Results: The ADC, D in LVI-positive group were lower, whereas tumor thickness and f parameter in LVI-positive group were higher than those in LVI-negative group, and they were statistically correlated with LVI (p < 0.05). D, f and tumor thickness were independent risk factors of LVI. The area under the curve of ADC, D, f, thickness, and the combined parameter (D + f + thickness) were 0.667, 0.754, 0.695, 0.792, and 0.876, respectively. The combined parameter demonstrated higher efficacy than any other parameters (p < 0.05).

Conclusion: The ADC, D, and f can effectively distinguish LVI status of GC. The D, f and thickness were independent predictors. The combination of the three predictors further improved the efficacy.

Trial registration: ClinicalTrials.gov NCT04028375.

Keywords: Diffusion magnetic resonance imaging; Lymphovascular invasion; Stomach neoplasms.

PubMed Disclaimer

References

    1. Sung H, Ferlay J, Siegel RL et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71:209-249. https://doi.org/10.3322/caac.21660 . - DOI - PubMed
    1. Cao W, Chen HD, Yu YW et al. (2021) Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl) 134:783-791. https://doi.org/10.1097/CM9.0000000000001474 . - DOI - PubMed
    1. Papageorge MV, de Geus SWL, Zheng J et al. (2021) The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma. J Gastrointest Surg 25:1363-1369. https://doi.org/10.1007/s11605-021-04993-4 . - DOI - PubMed
    1. Smyth EC, Nilsson M, Grabsch HI et al. (2020) Gastric cancer. Lancet 396:635-648. https://doi.org/10.1016/S0140-6736(20)31288-5 . - DOI - PubMed
    1. Amin MB, Greene FL, Edge SB et al. (2017) The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging. CA Cancer J Clin 67:93–99. https://doi.org/10.3322/caac.21388 .

Publication types

Associated data

LinkOut - more resources