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. 2023 Apr 21;23(1):88.
doi: 10.1186/s12902-023-01340-3.

Metabolic syndrome among people living with HIV on antiretroviral therapy in Mwanza, Tanzania

Evangelista Malindisa  1   2 , Emmanuel Balandya  3 , Marina Njelekela  3   4 , Benson R Kidenya  5 , Filbert Francis  6 , Blandina T Mmbaga  7 , Haruna Dika  8 , Eligius Lyamuya  3 , Bruno Sunguya  3 , John Bartlett  9 , George PrayGod  10
Affiliations

Metabolic syndrome among people living with HIV on antiretroviral therapy in Mwanza, Tanzania

Evangelista Malindisa et al. BMC Endocr Disord. .

Abstract

Background: HIV and antiretroviral drugs, particularly protease inhibitors and nucleoside reverse transcriptase inhibitors, may increase the risk of Metabolic Syndrome (MetS) among people living with HIV (PLHIV). However, following the introduction of better drugs like dolutegravir, data on the burden of MetS are limited. This study aimed to assess the prevalence of MetS and associated factors among PLHIV on antiretroviral therapy (ART) in Tanzania.

Methods: This was a cross-sectional study among PLHIV aged ≥ 18 years on antiretroviral therapy for ≥ 1 year at Bugando Medical Centre in Mwanza conducted in 2020. Demographic and healthy-lifestyle-related non-communicable disease risk factors data were collected. Additionally, data on lipid profile, blood glucose, blood pressure, and waist circumference were collected for analysis of MetS according to the International Diabetes Federation criteria. Factors associated with MetS were assessed using logistic regression. A P ≤ 0.05 was considered statistically significant.

Results: Data for 223 participants were analyzed. The mean (SD) age was 44 (± 12) years and 79.8% (178) were females. A majority 78% (174) were on a tenofovir, lamivudine,and dolutegravir regimen. About 12.1% (27) were either current or past smokers, 45.3% (101) were past alcohol drinkers, 22.9% (51) were current drinkers, 12.1% (27) reported taking ≥ 5 servings of vegetables and fruits per day and 5.8% (13) were physically inactive. The prevalence of MetS was 22.9%. The only factors that were associated with Mets were fat mass index and adequate intake of vegetables and fruits, (adjusted odds ratio (aOR) 2.9, 95% CI 1.0, 7.9, P = 0.04) and (aOR1.2, 95% CI 1.0, 1.3, P = 0.02), respectively).

Conclusion: The prevalence of MetS remains high among PLHIV. Adiposity and adequate fruit and vegetable intake increased the risk. The introduction of new ART regimens shows no effect on MetS prevalence. Research is needed to understand how lifestyle changes could reduce MetS in PLHIV.

Keywords: Antiretroviral therapy; HIV; MetS.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Distribution of metabolic syndrome traits among study participants [27]
See this image and copyright information in PMC

References

    1. UNAIDS. UNAIDS Data 2021. 2021.
    1. Dye AC, Williams BG, Title. Antiretroviral therapy is the principal cause of tuberculosis decline in southern and eastern Africa. 2018.
    1. Tiozzo E, Konefal J, Adwan S, Martinez LA, Villabona J, Lopez J, et al. A cross-sectional assessment of metabolic syndrome in HIV-infected people of low socio-economic status receiving antiretroviral therapy. Diabetol Metabolic Syndrome. 2015;7:1–8. doi: 10.1186/s13098-015-0008-5. - DOI - PMC - PubMed
    1. Msoka TF, Guilder GPV, Smulders YM, Furth MV, Bartlett JA, Agtmael MAV. Association of HIV-infection, antiretroviral treatment and metabolic syndrome with large artery stiffness : a cross-sectional study. 2019:1–8.
    1. Husain NE, Noor SK, Elmadhoun WM, Almobarak AO, Awadalla H, Woodward CL et al. Diabetes, metabolic syndrome and dyslipidemia in people living with HIV in Africa: Re-emerging challenges not to be forgotten. HIV/AIDS - Research and Palliative Care. 2017;9:193–202. - PMC - PubMed