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Randomized Controlled Trial
. 2023 Apr 21;23(1):96.
doi: 10.1186/s12893-023-01984-x.

Colectomy reconstruction for ulcerative colitis in Sweden and England: a multicenter prospective comparison between ileorectal anastomosis and ileal pouch-anal anastomosis after colectomy in patients with ulcerative colitis. (CRUISE-study)

Anton Risto  1   2 , Caroline Nordenvall  3   4 , Mohammed Deputy  5   6 , Maria Hermanson  7   8 , Ulrik Lindforss  3   4 , Mattias Block  7 , Omar Faiz  4   5 , Pär Myrelid  9   10
Affiliations
Randomized Controlled Trial

Colectomy reconstruction for ulcerative colitis in Sweden and England: a multicenter prospective comparison between ileorectal anastomosis and ileal pouch-anal anastomosis after colectomy in patients with ulcerative colitis. (CRUISE-study)

Anton Risto et al. BMC Surg. .

Abstract

Background: There are no prospective trials comparing the two main reconstructive options after colectomy for Ulcerative colitis, ileal pouch anal anastomosis and ileorectal anastomosis. An attempt on a randomized controlled trial has been made but after receiving standardized information patients insisted on choosing operation themselves.

Methods: Adult Ulcerative colitis patients subjected to colectomy eligible for both ileal pouch anastomosis and ileorectal anastomosis are asked to participate and after receiving standardized information the get to choose reconstructive method. Patients declining reconstruction or not considered eligible for both methods will be followed as controls. The CRUISE study is a prospective, non-randomized, multi-center, open-label, controlled trial on satisfaction, QoL, function, and complications between ileal pouch anal anastomosis and ileorectal anastomosis.

Discussion: Reconstruction after colectomy is a morbidity-associated as well as a resource-intensive activity with the sole purpose of enhancing function, QoL and patient satisfaction. The aim of this study is to provide the best possible information on the risks and benefits of each reconstructive treatment.

Trial registration: ClinicalTrials.gov Identifier: NCT05628701.

Keywords: Ileal pouch anal anastomosis; Ileoanal anastomosis; Reconstructive surgery; Ulcerative colitis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Inclusion and Exclusion criteria
Fig. 2
Fig. 2
Flow chart describing the selection of patients eligible for the study (green). The other patients (yellow) will be asked to participate as controls
Fig. 3
Fig. 3
Timeline describing the collection of QoL and functional score questionnaires in the study population
See this image and copyright information in PMC

References

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