Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Apr 21;20(1):30.
doi: 10.1186/s12987-023-00429-0.

A year in review: brain barriers and brain fluids research in 2022

Richard F Keep  1 , Hazel C Jones  2 , Mark G Hamilton  3 , Lester R Drewes  4
Affiliations
Editorial

A year in review: brain barriers and brain fluids research in 2022

Richard F Keep et al. Fluids Barriers CNS. .

Abstract

This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninges), signaling within the neurovascular unit and elements of the brain fluid systems. It further discusses how brain barriers and brain fluid systems are impacted in CNS diseases, their role in disease progression and progress being made in treating such diseases.

Keywords: Blood-brain barrier; Brain endothelium; Cerebrospinal fluid, choroid plexus, drug delivery; Glymphatics, hydrocephalus, neurovascular unit.

PubMed Disclaimer

Conflict of interest statement

RFK, HCJ, MGH and LRD are co-Editors-in-Chief of Fluids Barriers of the CNS.

References

    1. Ben-Zvi A, Liebner S. Developmental regulation of barrier- and non-barrier blood vessels in the CNS. J Intern Med. 2022;292(1):31–46. doi: 10.1111/joim.13263. - DOI - PubMed
    1. Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, et al. Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. Cell. 2022;185(20):3753–3769e3718. doi: 10.1016/j.cell.2022.09.004. - DOI - PMC - PubMed
    1. Tiedt S, Buchan AM, Dichgans M, Lizasoain I, Moro MA, Lo EH. The neurovascular unit and systemic biology in stroke - implications for translation and treatment. Nat Reviews Neurol. 2022;18(10):597–612. doi: 10.1038/s41582-022-00703-z. - DOI - PubMed
    1. Garcia FJ, Sun N, Lee H, Godlewski B, Mathys H, Galani K, Zhou B, Jiang X, Ng AP, Mantero J, et al. Single-cell dissection of the human brain vasculature. Nature. 2022;603(7903):893–9. doi: 10.1038/s41586-022-04521-7. - DOI - PMC - PubMed
    1. Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, et al. A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk. Nature. 2022;603(7903):885–92. doi: 10.1038/s41586-021-04369-3. - DOI - PMC - PubMed

Publication types

LinkOut - more resources