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Review
. 2023 Mar 20;43(3):495-498.
doi: 10.12122/j.issn.1673-4254.2023.03.22.

[Multiple primary malignancies combined with SWI/SNF complex-deficient gastric cancer: a case report and literature review]

[Article in Chinese]
C Lü  1   2 , X Wu  2 , Q Xia  2
Affiliations
Review

[Multiple primary malignancies combined with SWI/SNF complex-deficient gastric cancer: a case report and literature review]

[Article in Chinese]
C Lü et al. Nan Fang Yi Ke Da Xue Xue Bao. .

Abstract
in English, Chinese

Multiple primary malignancies combined with SWI/SNF complex-deficient gastric cancer is a rare clinical entity and poorly documented. Herein we report a case of this disease in an 81-year-old male patient treated in our hospital. Before the established diagnosis of metachronous multiple primary malignancies, the patient received left lower lobectomy for a spaceoccupying mass in the left lung, which was confirmed by postoperative pathology as early stage lung cancer. SWI/SNF complex-deficiency gastric cancer with metastasis was subsequently detected by gastroscopy, and high-throughput sequencing identified ARID1A and TMB-H gene mutations in the tumor tissues. The patient received chemotherapy combined with immunotherapy but failed to respond to the treatment, and died 13 months later. We conducted a literature review and analyzed the occurrence, pathological and immunohistochemical characteristics, diagnosis, treatment and prognosis of this disease.

多原发恶性肿瘤合并SWI/SNF复合体缺陷型胃癌的病例报道较少见。本例是由上海交通大学医学院附属仁济医院肿瘤科收治的1例多原发恶性肿瘤合并SWI/SNF复合体缺陷型胃癌的病例，通过分析临床病理特点、诊疗过程等，并结合文献复习，讨论该类肿瘤的发生、病理和免疫组化特征、诊治及预后。该例患者是异时性多原发恶性肿瘤，先确诊早期肺癌，经手术治愈，后确诊为SWI/SNF复合体缺陷型胃癌，合并ARID1A突变及TMB-H，经化疗联合免疫治疗效果不佳，总生存期13月。本报道旨在提高对多原发恶性肿瘤合并SWI/SNF复合体缺陷型胃癌的认知及诊治水平，改善患者的生存预后。

Keywords: SWI/SNF complex-deficiency; gastric cancer; multiple primary malignancies.

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Figures

图 1
图 1
肝转移灶治疗前后对比图 Comparison of hepatic metastases before and after treatment. A: Hepatic metastases before treatment; B: Hepatic metastases after treatment.
图 2
图 2
病情时间轴图 Timeline of treatment of the patient.
See this image and copyright information in PMC

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