Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar 20;43(3):495-498.
doi: 10.12122/j.issn.1673-4254.2023.03.22.

[Multiple primary malignancies combined with SWI/SNF complex-deficient gastric cancer: a case report and literature review]

[Article in Chinese]
C Lü  1   2 , X Wu  2 , Q Xia  2
Affiliations
Review

[Multiple primary malignancies combined with SWI/SNF complex-deficient gastric cancer: a case report and literature review]

[Article in Chinese]
C Lü et al. Nan Fang Yi Ke Da Xue Xue Bao. .

Abstract
in English, Chinese

Multiple primary malignancies combined with SWI/SNF complex-deficient gastric cancer is a rare clinical entity and poorly documented. Herein we report a case of this disease in an 81-year-old male patient treated in our hospital. Before the established diagnosis of metachronous multiple primary malignancies, the patient received left lower lobectomy for a spaceoccupying mass in the left lung, which was confirmed by postoperative pathology as early stage lung cancer. SWI/SNF complex-deficiency gastric cancer with metastasis was subsequently detected by gastroscopy, and high-throughput sequencing identified ARID1A and TMB-H gene mutations in the tumor tissues. The patient received chemotherapy combined with immunotherapy but failed to respond to the treatment, and died 13 months later. We conducted a literature review and analyzed the occurrence, pathological and immunohistochemical characteristics, diagnosis, treatment and prognosis of this disease.

多原发恶性肿瘤合并SWI/SNF复合体缺陷型胃癌的病例报道较少见。本例是由上海交通大学医学院附属仁济医院肿瘤科收治的1例多原发恶性肿瘤合并SWI/SNF复合体缺陷型胃癌的病例，通过分析临床病理特点、诊疗过程等，并结合文献复习，讨论该类肿瘤的发生、病理和免疫组化特征、诊治及预后。该例患者是异时性多原发恶性肿瘤，先确诊早期肺癌，经手术治愈，后确诊为SWI/SNF复合体缺陷型胃癌，合并ARID1A突变及TMB-H，经化疗联合免疫治疗效果不佳，总生存期13月。本报道旨在提高对多原发恶性肿瘤合并SWI/SNF复合体缺陷型胃癌的认知及诊治水平，改善患者的生存预后。

Keywords: SWI/SNF complex-deficiency; gastric cancer; multiple primary malignancies.

PubMed Disclaimer

Figures

图 1
图 1
肝转移灶治疗前后对比图 Comparison of hepatic metastases before and after treatment. A: Hepatic metastases before treatment; B: Hepatic metastases after treatment.
图 2
图 2
病情时间轴图 Timeline of treatment of the patient.
See this image and copyright information in PMC

References

    1. Lv M, Zhang X, Shen YW, et al. Clinical analysis and prognosis of synchronous and metachronous multiple primary malignant tumors. Medicine. 2017;96(17):e6799. doi: 10.1097/MD.0000000000006799. - DOI - PMC - PubMed
    1. Carlomagno N, Santangelo ML, Mastromarino R, et al. Rare multiple primary malignancies among surgical patients-a single surgical unit experience. Ecancermedicalscience. 2014;8:438. - PMC - PubMed
    1. Hodges C, Kirkland JG, Crabtree GR. The many roles of BAF (mSWI/SNF) and PBAF complexes in cancer. Cold Spring Harb Perspect Med. 2016;6(8):a026930. doi: 10.1101/cshperspect.a026930. - DOI - PMC - PubMed
    1. Mittal P, Roberts CWM. The SWI/SNF complex in cancer-biology, biomarkers and therapy. Nat Rev Clin Oncol. 2020;17(7):435–48. doi: 10.1038/s41571-020-0357-3. - DOI - PMC - PubMed
    1. Kim SH, Park BS, Kim HS, et al. Synchronous quintuple primary gastrointestinal tract malignancies: case report. World J Gastroenterol. 2017;23(1):173–7. doi: 10.3748/wjg.v23.i1.173. - DOI - PMC - PubMed

Substances

LinkOut - more resources