PNN reports grant or research support from Novo Nordisk; and consulting fees from AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Gilead, GSK, Intercept, Madrigal, Novo Nordisk, Pfizer, and Sun Pharma, on behalf of the University of Birmingham, Birmingham, UK, unrelated to this Comment. PNN was supported by the Birmingham National Institute for Health and Care Research (NIHR) Biomedical Research Centre. The views expressed in this Comment are informed by independent research supported in part by NIHR Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham (BRC-1215-20009). The views expressed are those of the authors and not necessarily those of the NIHR or the UK Department of Health and Social Care. SM declares no competing interests.