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. 2023 Jul;11(7):2125-2132.e1.
doi: 10.1016/j.jaip.2023.03.059. Epub 2023 Apr 23.

Early-Life Weight Status and Risk of Childhood Asthma or Recurrent Wheeze in Preterm and Term Offspring

Jhill Shah  1 , Iskander L C Shadid  2 , Vincent J Carey  3 , Nancy Laranjo  3 , George T O'Connor  4 , Robert S Zeiger  5 , Leonard Bacharier  6 , Augusto A Litonjua  7 , Scott T Weiss  3 , Hooman Mirzakhani  8
Affiliations

Early-Life Weight Status and Risk of Childhood Asthma or Recurrent Wheeze in Preterm and Term Offspring

Jhill Shah et al. J Allergy Clin Immunol Pract. 2023 Jul.

Abstract

Background: Excessive weight is associated with the development of childhood asthma. However, trends among preterm and term offspring may differ.

Objective: To assess whether the association of longitudinal weight for age (WFA) and odds of asthma/recurrent wheeze in early life differs between children born preterm and those born at term.

Methods: This study used prospectively collected data from the Vitamin D Antenatal Asthma Reduction Trial. Children (n = 804) were followed-up and anthropometric measurements, including WFA, were taken at birth and annually until the age of 6 years. The primary outcome was asthma/recurrent wheeze by age 3 and 6 years.

Results: Among the offspring, 71 (8.8%) were premature. In all the children, the odds of asthma/recurrent wheeze increased by 15% (adjusted odds ratio [aOR], 1.15; 95% CI, 1.10-1.20; P < .001) by age 3 years and 9% (aOR, 1.09; 95% CI, 1.07-1.11; P < .001) by age 6 years for each unit increase in WFA z score. Odds were different between term and preterm offspring (Pinteraction < .001). In term offspring, the odds of having asthma/recurrent wheeze by age 3 and 6 years increased by 22% and 15%, respectively (aOR, 1.22, 95% CI, 1.16-1.27, P < .001, and aOR, 1.15, 95% CI, 1.11-1.18, P < .001). In preterm offspring, by age 3 years, odds of asthma/recurrent wheeze decreased by 10% for each unit increase in WFA z score (aOR, 0.90; 95% CI, 0.81-0.99; P = .030) and decreased by 27% by age 6 years (aOR, .73; 95% CI, 0.61-0.86; P < .001).

Conclusions: During early life, increasing standardized WFA is associated with higher odds of asthma/recurrent wheeze in term children. In contrast, in preterm children, a higher standardized WFA during catch-up growth may decrease the odds of asthma/recurrent wheeze associated with prematurity.

Keywords: Childhood asthma; Growth; Preterm birth; Weight; Z score.

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Figures

Figure 1.
Figure 1.. The VDAART participant flow diagram and study subjects.
CONSORT diagram of VDAART.
Figure 2.
Figure 2.. Estimated Pearson correlation between weight for age (WFA) z-scores and body mass index (BMI) z-scores in the first 6 years of life.
Timepoints shown are at birth (Birth), year 1 (Y1), year 2 (Y2), year 3 (Y3), year 4 (Y4) and year 5 (Y5), in conjunction with the measure of interest WFA or BMI.
Figure 3.
Figure 3.. The trend of weight for age z-scores among preterm and term offspring during the first 6 years of life.
a) WFA z-scores vs. offspring age in years among preterm and term offspring. b) Comparison between annual WFA z-scores among preterm and term offspring through 6 years of age.
See this image and copyright information in PMC

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