The use of biomarkers to guide precision treatment for tobacco use

doi:10.1016/j.addicn.2023.100076

. 2023 Jun:6:100076.

doi: 10.1016/j.addicn.2023.100076. Epub 2023 Feb 16.

The use of biomarkers to guide precision treatment for tobacco use

Scott D Siegel¹, Hilary A Tindle², Andrew W Bergen³, Rachel F Tyndale^{4

5}, Robert Schnoll⁶

Affiliations

¹ Christiana Care Health System, Helen F. Graham Cancer Center & Research Institute and Institute for Research on Equity & Community Health, 4701, gletown-Stanton Road, Newark, DE 19713, United States.
² Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, United States.
³ Oregon Research Institute, United States.
⁴ Departments of Pharmacology & Toxicology, and Psychiatry, University of Toronto and Centre for Addiction and Mental Health, Canada.
⁵ Geriatric Research Education and Clinical Centers, Veterans Affairs Tennessee Valley Healthcare System, Nashville, United States.
⁶ Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, United States.

PMID: 37089247
PMCID: PMC10121195
DOI: 10.1016/j.addicn.2023.100076

The use of biomarkers to guide precision treatment for tobacco use

Scott D Siegel et al. Addict Neurosci. 2023 Jun.

. 2023 Jun:6:100076.

doi: 10.1016/j.addicn.2023.100076. Epub 2023 Feb 16.

Authors

Scott D Siegel¹, Hilary A Tindle², Andrew W Bergen³, Rachel F Tyndale^{4

5}, Robert Schnoll⁶

Affiliations

¹ Christiana Care Health System, Helen F. Graham Cancer Center & Research Institute and Institute for Research on Equity & Community Health, 4701, gletown-Stanton Road, Newark, DE 19713, United States.
² Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, United States.
³ Oregon Research Institute, United States.
⁴ Departments of Pharmacology & Toxicology, and Psychiatry, University of Toronto and Centre for Addiction and Mental Health, Canada.
⁵ Geriatric Research Education and Clinical Centers, Veterans Affairs Tennessee Valley Healthcare System, Nashville, United States.
⁶ Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, United States.

PMID: 37089247
PMCID: PMC10121195
DOI: 10.1016/j.addicn.2023.100076

Abstract

This review summarizes the evidence to date on the development of biomarkers for personalizing the pharmacological treatment of combustible tobacco use. First, the latest evidence on FDA-approved medications is considered, demonstrating that, while these medications offer real benefits, they do not contribute to smoking cessation in approximately two-thirds of cases. Second, the case for using biomarkers to guide tobacco treatment is made based on the potential to increase medication effectiveness and uptake and reduce side effects. Next, the FDA framework of biomarker development is presented along with the state of science on biomarkers for tobacco treatment, including a review of the nicotine metabolite ratio, electroencephalographic event-related potentials, and other biomarkers utilized for risk feedback. We conclude with a discussion of the challenges and opportunities for the translation of biomarkers to guide tobacco treatment and propose priorities for future research.

Keywords: Biomarker; Nicotine metabolite ratio; Precision treatment; Smoking cessation; Tobacco treatment.

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[1] Davis KD, Aghaeepour N, Ahn AH, Angst MS, Borsook D, Brenton A, Burczynski ME, et al., Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities, Nat. Rev. Neurol 16 (7) (2020) 381–400, doi: 10.1038/s41582-020-0362-2. - DOI - PMC - PubMed

[2] Davis KD, Aghaeepour N, Ahn AH, Angst MS, Borsook D, Brenton A, Burczynski ME, et al., Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities, Nat. Rev. Neurol 16 (7) (2020) 381–400, doi: 10.1038/s41582-020-0362-2. - DOI - PMC - PubMed

[3] Bierut LJ, RF. Tyndale, Preparing the way: exploiting genomic medicine to stop smoking, Trends Mol. Med 24 (2) (2018) 187–196, doi: 10.1016/j.molmed.2017.12.001. - DOI - PMC - PubMed

[4] Bierut LJ, RF. Tyndale, Preparing the way: exploiting genomic medicine to stop smoking, Trends Mol. Med 24 (2) (2018) 187–196, doi: 10.1016/j.molmed.2017.12.001. - DOI - PMC - PubMed

[5] Patnode CD, Henderson JT, Melnikow J, Coppola EL, Durbin S, Thomas R Interventions for tobacco cessation in adults, including pregnant women: an evidence update for the U.S. preventive services task force. Evidence Synthesis, No 196. AHRQ publication No. 20–05264-EF-1. US Prev Serv Task Force Evid Synth Former Syst Evid Rev Rockv Agency Healthc Res Qual. 2021;(196). https://www.ncbi.nlm.nih.gov/books/NBK567066/ - PubMed

[6] Patnode CD, Henderson JT, Melnikow J, Coppola EL, Durbin S, Thomas R Interventions for tobacco cessation in adults, including pregnant women: an evidence update for the U.S. preventive services task force. Evidence Synthesis, No 196. AHRQ publication No. 20–05264-EF-1. US Prev Serv Task Force Evid Synth Former Syst Evid Rev Rockv Agency Healthc Res Qual. 2021;(196). https://www.ncbi.nlm.nih.gov/books/NBK567066/ - PubMed

[7] Krist AH, Davidson KW, Mangione CM, Barry MJ, Cabana M, Caughey AB, Donahue K, et al., Interventions for tobacco smoking cessation in adults, including pregnant persons: US preventive services task force recommendation statement, JAMA 325 (3) (2021) 265–279, doi: 10.1001/jama.2020.25019. - DOI - PubMed

[8] Krist AH, Davidson KW, Mangione CM, Barry MJ, Cabana M, Caughey AB, Donahue K, et al., Interventions for tobacco smoking cessation in adults, including pregnant persons: US preventive services task force recommendation statement, JAMA 325 (3) (2021) 265–279, doi: 10.1001/jama.2020.25019. - DOI - PubMed

[9] Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T, Nicotine replacement therapy versus control for smoking cessation, Cochrane Database Syst. Rev. 2018. (5) (2018), doi: 10.1002/14651858.CD000146.pub5. - DOI - PMC - PubMed

[10] Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T, Nicotine replacement therapy versus control for smoking cessation, Cochrane Database Syst. Rev. 2018. (5) (2018), doi: 10.1002/14651858.CD000146.pub5. - DOI - PMC - PubMed

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The use of biomarkers to guide precision treatment for tobacco use

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The use of biomarkers to guide precision treatment for tobacco use

Authors

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Abstract

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