Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group

Huisheng Ai¹, Nelson J Chao², David A Rizzieri³, Xiaojun Huang⁴, Thomas R Spitzer⁵, Jianxiang Wang⁶, Mei Guo¹, Armand Keating⁷, Elizabeth F Krakow⁸, Didier Blaise⁹, Jun Ma¹⁰, Depei Wu¹¹, John Reagan¹², Usama Gergis¹³, Rafael F Duarte¹⁴, Preet M Chaudhary¹⁵, Kaixun Hu¹, Changlin Yu¹, Qiyun Sun¹, Ephraim Fuchs¹⁶, Bo Cai¹, Yajing Huang^{1

17}, Jianhui Qiao¹, David Gottlieb¹⁸, Kirk R Schultz¹⁹, Mingyao Liu⁷, Xiequn Chen²⁰, Wenming Chen²¹, Jianmin Wang²², Xiaohui Zhang⁴, Jianyong Li²³, He Huang²⁴, Zimin Sun²⁵, Fei Li²⁶, Linhua Yang²⁷, Liansheng Zhang²⁸, Lijuan Li²⁸, Kaiyan Liu⁴, Jie Jin²⁴, Qifa Liu²⁹, Daihong Liu¹, Chunji Gao¹, Chuanbo Fan³⁰, Li Wei³¹, Xi Zhang³², Liangding Hu¹, Weijing Zhang³³, Yuyang Tian³⁴, Weidong Han¹, Jun Zhu³⁵, Zhijian Xiao⁶, Daobin Zhou³⁶, Bolong Zhang¹⁰, Yongqian Jia³⁷, Yongqing Zhang¹, Xiaoxiong Wu¹, Xuliang Shen³⁸, Xuzhang Lu³⁹, Xinrong Zhan⁴⁰, Xiuli Sun⁴¹, Yi Xiao⁴², Jingbo Wang⁴³, Xiaodong Shi⁴⁴, Bo Zheng⁴⁵, Jieping Chen⁴⁶, Banghe Ding⁴⁷, Zhao Wang⁴⁸, Fan Zhou⁴⁹, Mei Zhang⁵⁰, Yizhuo Zhang⁵¹, Jie Sun²⁴, Bing Xia⁵², Baoan Chen⁵³, Liangming Ma⁵⁴

Affiliations

¹ Chinese PLA General Hospital, China.
² Duke University, USA.
³ Novant Health, USA.
⁴ People's Hospital of Peking University, China.
⁵ Massachusetts General Hospital, USA.
⁶ Chinese Academy of Medical Sciences Hematology Hospital, China.
⁷ University of Toronto, Canada.
⁸ Fred Hutchinson Cancer Research Center, USA.
⁹ Marseille Cancer Research Center, France.
¹⁰ Harbin Institute of Hematology and Oncology, China.
¹¹ The First Affiliated Hospital of Soochow University, China.
¹² The Warren Alpert Medical School of Brown University, USA.
¹³ Sidney Kimmel Cancer Center, USA.
¹⁴ Hospital Universitario Puerta de Hierro, Spain.
¹⁵ Keck School of Medicine of University of Southern California, USA.
¹⁶ Johns Hopkins University, USA.
¹⁷ Innovvy (Beijing) Biomedical Technology Co.Ltd, China.
¹⁸ Westmead Hospital, Australia.
¹⁹ BC Children's Hospital and Research Institute, Canada.
²⁰ Affiliated Hospital of Northwest University, China.
²¹ Beijing Chao-yang Hospital, Capital Medical University, China.
²² Changhai Hospital of Naval Medical University, China.
²³ Jiangsu Province Hospital, China.
²⁴ The First Affiliated Hospital, Zhejiang University School of Medicine, China.
²⁵ The First Affiliated Hospital of University of Science and Technology of China, China.
²⁶ The First Affiliated Hospital of Nanchang University, China.
²⁷ The Second Hospital of Shanxi Medical University, China.
²⁸ Lanzhou University Second Hospital, China.
²⁹ Nanfang Hospital of Southern Medical University, China.
³⁰ Qingdao Hiser Hospital, China.
³¹ Chengdu Fifth People's Hospital, China.
³² Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Jinfeng Laboratory, China.
³³ Beijing Shijitan Hospital, China.
³⁴ Hainan Cancer Hospital, China.
³⁵ Beijing Cancer Hospital, China.
³⁶ Peking Union Medical College Hospital, China.
³⁷ West China Hospital of Sichuan University, China.
³⁸ Heping Hospital Affiliated to Changzhi Medical College, China.
³⁹ Changzhou Second People's Hospital, China.
⁴⁰ Xinxiang Center Hospital, China.
⁴¹ The First Affiliated Hospital of Dalian Medical University, China.
⁴² Tongji Hospital, Tongji Medical College of HUST, China.
⁴³ Aerospace Center Hospital, China.
⁴⁴ Capital Institute of Pediatrics, China.
⁴⁵ General Hospital of Ningxia Medical University, China.
⁴⁶ Southwest Hospital of Army Medical University, China.
⁴⁷ Huai'an First People's Hospital, China.
⁴⁸ Beijing Friendship Hospital, Capital Medical University, China.
⁴⁹ General Hospital of Northern Theater Command, China.
⁵⁰ The First Affiliated Hospital of Xi'an Jiaotong University, China.
⁵¹ Sun Yat-sen University Cancer Center, China.
⁵² Tianjin Medical University Cancer Institute and Hospital, China.
⁵³ Zhongda Hospital, Southeast University, China.
⁵⁴ Shanxi Bethune Hospital, China.

PMID: 37089296
PMCID: PMC10119710
DOI: 10.1016/j.heliyon.2023.e14924

Review

Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group

Huisheng Ai et al. Heliyon. 2023.

. 2023 Mar 31;9(4):e14924.

doi: 10.1016/j.heliyon.2023.e14924. eCollection 2023 Apr.

Authors

Affiliations

¹ Chinese PLA General Hospital, China.
² Duke University, USA.
³ Novant Health, USA.
⁴ People's Hospital of Peking University, China.
⁵ Massachusetts General Hospital, USA.
⁶ Chinese Academy of Medical Sciences Hematology Hospital, China.
⁷ University of Toronto, Canada.
⁸ Fred Hutchinson Cancer Research Center, USA.
⁹ Marseille Cancer Research Center, France.
¹⁰ Harbin Institute of Hematology and Oncology, China.
¹¹ The First Affiliated Hospital of Soochow University, China.
¹² The Warren Alpert Medical School of Brown University, USA.
¹³ Sidney Kimmel Cancer Center, USA.
¹⁴ Hospital Universitario Puerta de Hierro, Spain.
¹⁵ Keck School of Medicine of University of Southern California, USA.
¹⁶ Johns Hopkins University, USA.
¹⁷ Innovvy (Beijing) Biomedical Technology Co.Ltd, China.
¹⁸ Westmead Hospital, Australia.
¹⁹ BC Children's Hospital and Research Institute, Canada.
²⁰ Affiliated Hospital of Northwest University, China.
²¹ Beijing Chao-yang Hospital, Capital Medical University, China.
²² Changhai Hospital of Naval Medical University, China.
²³ Jiangsu Province Hospital, China.
²⁴ The First Affiliated Hospital, Zhejiang University School of Medicine, China.
²⁵ The First Affiliated Hospital of University of Science and Technology of China, China.
²⁶ The First Affiliated Hospital of Nanchang University, China.
²⁷ The Second Hospital of Shanxi Medical University, China.
²⁸ Lanzhou University Second Hospital, China.
²⁹ Nanfang Hospital of Southern Medical University, China.
³⁰ Qingdao Hiser Hospital, China.
³¹ Chengdu Fifth People's Hospital, China.
³² Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Jinfeng Laboratory, China.
³³ Beijing Shijitan Hospital, China.
³⁴ Hainan Cancer Hospital, China.
³⁵ Beijing Cancer Hospital, China.
³⁶ Peking Union Medical College Hospital, China.
³⁷ West China Hospital of Sichuan University, China.
³⁸ Heping Hospital Affiliated to Changzhi Medical College, China.
³⁹ Changzhou Second People's Hospital, China.
⁴⁰ Xinxiang Center Hospital, China.
⁴¹ The First Affiliated Hospital of Dalian Medical University, China.
⁴² Tongji Hospital, Tongji Medical College of HUST, China.
⁴³ Aerospace Center Hospital, China.
⁴⁴ Capital Institute of Pediatrics, China.
⁴⁵ General Hospital of Ningxia Medical University, China.
⁴⁶ Southwest Hospital of Army Medical University, China.
⁴⁷ Huai'an First People's Hospital, China.
⁴⁸ Beijing Friendship Hospital, Capital Medical University, China.
⁴⁹ General Hospital of Northern Theater Command, China.
⁵⁰ The First Affiliated Hospital of Xi'an Jiaotong University, China.
⁵¹ Sun Yat-sen University Cancer Center, China.
⁵² Tianjin Medical University Cancer Institute and Hospital, China.
⁵³ Zhongda Hospital, Southeast University, China.
⁵⁴ Shanxi Bethune Hospital, China.

PMID: 37089296
PMCID: PMC10119710
DOI: 10.1016/j.heliyon.2023.e14924

Abstract

Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, based on analysis of the literature on MST, especially MST with EAML from January 1st, 2011 to November 30th, 2022, the International Microtransplant Interest Group provides recommendations and considerations for MST in the treatment of EAML. Four major issues related to MST for treating EAML were addressed: therapeutic principle of MST (1), candidates for MST (2), induction chemotherapy regimens (3), and post-remission therapy based on MST (4). Others included donor screening, infusion of donor cells, laboratory examinations, and complications of treatment.

Keywords: Acute myeloid leukemia; Elderly; Microtransplant; Recommendations and considerations.

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References

1. Dohner H., Weisdorf D.J., Bloomfield C.D. Acute myeloid leukemia. N. Engl. J. Med. 2015;373(12):1136–1152. - PubMed
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1. Rizzieri D.A., O'Brien J.A., Broadwater G., et al. Outcomes of patients who undergo aggressive induction therapy for secondary acute myeloid leukemia. Cancer. 2009;115(13):2922–2929. - PubMed
1. Farag S.S., Archer K.J., Mrózek K., et al. Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461. Blood. 2006;108(1):63–73. - PMC - PubMed
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Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group

Affiliations

Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group

Authors

Affiliations

Abstract

References

Publication types

LinkOut - more resources

Full Text Sources