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Review
. 2023 Apr 6:14:1137058.
doi: 10.3389/fphys.2023.1137058. eCollection 2023.

Mouse models of preeclampsia with preexisting comorbidities

Christopher A Waker  1 , Amy E Hwang  1 , Scout Bowman-Gibson  1 , Chandni H Chandiramani  1   2 , Bryce Linkous  1 , Madison L Stone  1 , Chanel I Keoni  1 , Melissa R Kaufman  1 , Thomas L Brown  1   2
Affiliations
Review

Mouse models of preeclampsia with preexisting comorbidities

Christopher A Waker et al. Front Physiol. .

Abstract

Preeclampsia is a pregnancy-specific condition and a leading cause of maternal and fetal morbidity and mortality. It is thought to occur due to abnormal placental development or dysfunction, because the only known cure is delivery of the placenta. Several clinical risk factors are associated with an increased incidence of preeclampsia including chronic hypertension, diabetes, autoimmune conditions, kidney disease, and obesity. How these comorbidities intersect with preeclamptic etiology, however, is not well understood. This may be due to the limited number of animal models as well as the paucity of studies investigating the impact of these comorbidities. This review examines the current mouse models of chronic hypertension, pregestational diabetes, and obesity that subsequently develop preeclampsia-like symptoms and discusses how closely these models recapitulate the human condition. Finally, we propose an avenue to expand the development of mouse models of preeclampsia superimposed on chronic comorbidities to provide a strong foundation needed for preclinical testing.

Keywords: comorbidity; diabetes; hypertension; mouse model; obesity; preeclampsia.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Clinical risk factors for the development of preeclampsia (SMFM Patient Safety and Quality Committee et al., 2020; Obstetrics and Gynecology, 2020). Created with BioRender.com.
See this image and copyright information in PMC

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