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Review
. 2023 Apr 6:10:1150336.
doi: 10.3389/fcvm.2023.1150336. eCollection 2023.

A review of biomarker and imaging monitoring to predict heart failure recovery

Crystal Lihong Yan  1 , Luanda Grazette  2
Affiliations
Review

A review of biomarker and imaging monitoring to predict heart failure recovery

Crystal Lihong Yan et al. Front Cardiovasc Med. .

Abstract

Heart failure is a clinical syndrome caused by structural cardiac abnormalities that lead to increased intracardiac pressures and decreased cardiac output. Following cardiovascular insult or direct myocardial injury, neurohormonal activation triggers hemodynamic changes and cardiac remodeling to preserve cardiac output. While initially adaptive, cardiac remodeling eventually causes pathologic changes in cardiac structure that often compromise cardiac function. Reverse remodeling is the regression of abnormal cardiac chamber geometry and function after myocardial injury. In recent years, several classes of therapeutics have been associated with greater likelihood of reverse remodeling. Heart failure recovery and heart failure remission, terms encompassing the clinical correlates of reverse remodeling, have been associated with improved survival in patients with heart failure with reduced ejection. As such, identifying predictors of heart failure recovery can have important implications for guiding clinical practice and therapeutic innovation. This review addresses the role of biomarkers and imaging monitoring in predicting structural, functional, and clinical recovery in patients with acute and chronic heart failure.

Keywords: biomarker monitoring; heart failure; heart failure recovery; imaging monitoring; predictors; reverse remodeling.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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