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Review
. 2023 Apr 6:14:1045309.
doi: 10.3389/fphar.2023.1045309. eCollection 2023.

Evaluation of mulberry leaves' hypoglycemic properties and hypoglycemic mechanisms

Sikai Chen  1 , Miaomiao Xi  2   3 , Feng Gao  1 , Min Li  1 , TaiWei Dong  1 , Zhixin Geng  1 , Chunyu Liu  1 , Fengyu Huang  1 , Jing Wang  1 , Xingyu Li  1 , Peifeng Wei  1   2 , Feng Miao  2
Affiliations
Review

Evaluation of mulberry leaves' hypoglycemic properties and hypoglycemic mechanisms

Sikai Chen et al. Front Pharmacol. .

Abstract

The effectiveness of herbal medicine in treating diabetes has grown in recent years, but the precise mechanism by which it does so is still unclear to both medical professionals and diabetics. In traditional Chinese medicine, mulberry leaf is used to treat inflammation, colds, and antiviral illnesses. Mulberry leaves are one of the herbs with many medicinal applications, and as mulberry leaf study grows, there is mounting evidence that these leaves also have potent anti-diabetic properties. The direct role of mulberry leaf as a natural remedy in the treatment of diabetes has been proven in several studies and clinical trials. However, because mulberry leaf is a more potent remedy for diabetes, a deeper understanding of how it works is required. The bioactive compounds flavonoids, alkaloids, polysaccharides, polyphenols, volatile oils, sterols, amino acids, and a variety of inorganic trace elements and vitamins, among others, have been found to be abundant in mulberry leaves. Among these compounds, flavonoids, alkaloids, polysaccharides, and polyphenols have a stronger link to diabetes. Of course, trace minerals and vitamins also contribute to blood sugar regulation. Inhibiting alpha glucosidase activity in the intestine, regulating lipid metabolism in the body, protecting pancreatic -cells, lowering insulin resistance, accelerating glucose uptake by target tissues, and improving oxidative stress levels in the body are some of the main therapeutic properties mentioned above. These mechanisms can effectively regulate blood glucose levels. The therapeutic effects of the bioactive compounds found in mulberry leaves on diabetes mellitus and their associated molecular mechanisms are the main topics of this paper's overview of the state of the art in mulberry leaf research for the treatment of diabetes mellitus.

Keywords: chemical substances in mulberry leaves; diabetes treatmen; molecular mechanism; mulberry leaves; mulberry leaves safety.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Mechanism of blood glucose regulation by improving oxidative stress in mulberry leaves.
FIGURE 2
FIGURE 2
Mechanisms by which mulberry leaves improve insulin resistance to regulate blood glucose.
See this image and copyright information in PMC

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