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. 2023 Mar 22:40:44-46.
doi: 10.1016/j.mmcr.2023.03.005. eCollection 2023 Jun.

Peritonitis due to Aspergillus tamarii in peritoneal dialysis patients

Uraiwan Parinyasiri  1 , Sriphrae Uppamai  2 , Tamonwan Chamroensakchai  3 , Sirirat Sirinual  2 , Korawee Sukmee  1 , Athiphat Banjongjit  4 , Talerngsak Kanjanabuch  3   5   6
Affiliations

Peritonitis due to Aspergillus tamarii in peritoneal dialysis patients

Uraiwan Parinyasiri et al. Med Mycol Case Rep. .

Abstract

Aspergillus peritonitis is uncommon, but it is associated with high mortality and morbidity in patients undergoing peritoneal dialysis (PD). We report two cases of Aspergillus tamarii peritonitis that were initially misidentified as A. flavus by the conventional culture method. Nucleotide sequences of internal transcribed spacer regions of the ribosomal DNA gene as A. tamarii correctly identified the isolate. Despite early catheter removal and an appropriate antifunal agent, both patients had dismal outcomes. Nucleic acid sequencing offers an additional tool for better diagnosing the species within the genus of pathogenic microbes.

Keywords: Aspergillus; Aspergillus flavus; Aspergillus tamarii; Peritoneal dialysis; Peritonitis.

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Conflict of interest statement

TK has received consultancy fees from VISTERRA, ELEDON, Otsuka OLE, and Otsuka VISIONARY as country investigators and is a current recipient of the National Research Council of Thailand and received speaking honoraria from Astra Zeneca and Baxter Healthcare. The other authors declare that they have no relevant financial interests.

Figures

Fig. 1
Fig. 1
(A) The brown particle in PD catheter from patient case #2. (B) Aspergillus tamarii colony on SDA after 7 days of incubation at 25 °C. (C) A. tamari colony on SDA after 21 days of incubation at 25 °C. (D) The conidiophores of A. tamarii by KOH examination ( × 400). (E) The conidiophores of A. tamarii with blue color by Lactophenol cotton blue mount ( × 400). (F) The conidia of A. tamarii with blue color by Lactophenol cotton blue staining with 1000x magnification. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
See this image and copyright information in PMC

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