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Review
. 2023 Apr 6:14:1149931.
doi: 10.3389/fimmu.2023.1149931. eCollection 2023.

Role of CD147 in the development and diagnosis of hepatocellular carcinoma

Defa Huang  1 , Dingyu Rao  2 , Qing Jin  1 , Mi Lai  1 , Jiali Zhang  3 , Zhonghong Lai  4 , Haibin Shen  1 , Tianyu Zhong  1   5
Affiliations
Review

Role of CD147 in the development and diagnosis of hepatocellular carcinoma

Defa Huang et al. Front Immunol. .

Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and progression is imperative to development of effective diagnostic and therapeutic strategies. CD147 is a glycoprotein that is involved in tumor cell invasion, metastasis and angiogenesis through multiple mechanisms. In this review, we describe the molecular structure of CD147 and its role in regulating HCC invasion, metastasis and angiogenesis. We highlight its potential as a diagnostic and therapeutic target for HCC.

Keywords: CD147; angiogenesis; diagnosis; hepatocellular carcinoma; metastasis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Structural characteristics of CD147. CD147’s extracellular segments differed significantly. D0: retina-specific structural domain; D1: Ig C2 structural domain; D2: Ig I structural domain.
Figure 2
Figure 2
CD147 promotes hepatocellular carcinoma invasion and metastasis. CD147 promotes HCC invasion and metastasis mainly through FAK-PI3K-Ca2+, RhoA/ROCK, FAK-PI3K/PIP3,TGF-β and MAPK signaling pathways.
Figure 3
Figure 3
CD147 promotes hepatocellular carcinoma angiogenesis. CD147 enhances production of MMPs and VEGF thereby promoting HCC angiogenesis.
See this image and copyright information in PMC

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