Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar 21:19:100368.
doi: 10.1016/j.lrr.2023.100368. eCollection 2023.

Consolidation and maintenance therapy with bortezomib for Vietnamese patients with multiple myeloma after autologous transplantation

Minh Phuong Vu  1   2 , Thi Van Oanh Kieu  2 , Hoang Vu  2
Affiliations
Review

Consolidation and maintenance therapy with bortezomib for Vietnamese patients with multiple myeloma after autologous transplantation

Minh Phuong Vu et al. Leuk Res Rep. .

Abstract

Thirty patients with newly diagnosed symtomatic MM (multiple myeloma) received ASCT (autologous stem cell transplantation) and two cycles of bortezomib-cyclophosphamide-dexamethasone as consolidation treatment followed by maintenance of bortezomib for 24 months. 16 patients achieved complete response (CR) after ASCT, and two more patients achieved CR after consolidation therapy. At 92 months of follow-up, the median OS was 69.5 months, the median PFS was 38.5 months. OS and PFS in the high-risk group were shorter than in the standard-risk group with a statistically significant difference (p = 0.028, 0.049; respectively). Post-ASCT consolidation and maintenance therapy using bortezomib were effective in patients with MM.

Keywords: Consolidation therapy, Maintenance therapy; Multiple myeloma; Post- ASCT.

PubMed Disclaimer

Conflict of interest statement

All authors have stated that they have no conflict of interest

Figures

Fig 1:
Fig. 1
OS (Overall survival) and PFS (Progression -free survival) according to Cytogenetic risk.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. hamed Rama al, Bazarbachi Abdul Hamid, Malard Florent, Harousseau Jean-Luc, Mohty Mohamad. Current status of autologous stem cell transplatation for multiple myeloma. Blood Cancer J. 2019;9(4):44. - PMC - PubMed
    1. Miguel Jesus F San, Mateos Maria Victoria. Can multiple myeloma become a curable disease? Haematologica. 2011;96(9):1246–1248. Sep. - PMC - PubMed
    1. Mohty M., Richardson P.G., Attai M. Consolidation and maintenanace therapy for multiple myeloma after autologous transplantation: where do we stand? Bone Marrow Transplant. 2015;50:1024–12Q029. - PubMed
    1. Kumar Shaji K., Buadi Francis K, Vincent Rajkumar S. Pros and cons of frontline autologous transplantation in multiple myeloma. Blood. 2019;133(7):652–659. - PubMed
    1. Stadtmauer Edward A., Pasquini Marcelo C., Blackwell Beth, Hari Parameswaran, Bashey Asd, et al. Consoliadtion and maintenance therapy in multiple myeloma: results of the BMt CTN 0702 Trial. J. Clinic. Oncol. 2019;37(7):589–597. - PMC - PubMed

LinkOut - more resources