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. 2023 Feb 27;8(2):495-504.
doi: 10.1002/lio2.1031. eCollection 2023 Apr.

Jackson Heart Study: Aggregate cardiovascular disease risk and auditory profiles

Rachael R Baiduc  1 , Christopher Spankovich  2 , Thanh-Huyen Vu  3 , Alberto A Arteaga  2 , Charles Bishop  2 , John M Schweinfurth  2
Affiliations

Jackson Heart Study: Aggregate cardiovascular disease risk and auditory profiles

Rachael R Baiduc et al. Laryngoscope Investig Otolaryngol. .

Abstract

Objectives: Evaluate the relationship between cardiovascular disease (CVD) risk factors and cochlear function in African Americans.

Methods: Relationships between hearing loss, cochlear function, and CVD risk factors were assessed in a cross-sectional analysis of 1106 Jackson Heart Study participants. Hearing loss was defined as puretone average (PTA0.5,1,2,4) > 15 dB HL. Distortion product otoacoustic emissions (DPOAEs) were collected for f 2 = 1.0-8.0 kHz. Two amplitude averages were computed: DPOAElow (f 2 ≤ 4 kHz) and DPOAEhigh (f 2 ≥ 6 kHz). Based on major CVD risk factors (diabetes, current smoking, total cholesterol ≥240 mg/dL or treatment, and systolic blood pressure [BP]/diastolic BP ≥ 140/≥90 mmHg or treatment), four risk groups were created: 0, 1, 2, and ≥3 risk factors. Logistic regression estimated the odds of hearing loss and absent/reduced DPOAElow and DPOAEhigh by CVD risk status adjusting for age, sex, education, BMI, vertigo, and noise exposure.

Results: With multivariable adjustment, diabetes was associated with hearing loss (OR = 1.48 [95% CI: 1.04-2.10]). However, there was not a statistically significant relationship between CVD risk factors (individually or for overall risk) and DPOAEs.

Conclusion: Diabetes was associated with hearing loss. Neither individual CVD risk factors nor overall risk showed a relationship to cochlear dysfunction.

Level of evidence: 2b.

Keywords: Jackson Heart Study; audiology; cardiovascular disease risk factors; distortion product otoacoustic emissions; hearing loss; otology; sensorineural hearing loss.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of participant exclusions. DPOAE data missing if <2 data points contribute to the average. BMI, body mass index; CVD, cardiovascular disease; DPOAE, distortion product otoacoustic emission.
See this image and copyright information in PMC

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