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Review
. 2023 Apr 5:13:1165380.
doi: 10.3389/fonc.2023.1165380. eCollection 2023.

Animal models of cancer metastasis to the bone

Yihan Yu  1 , Kanglu Li  1 , Yizhong Peng  1 , Wei Wu  1 , Fengxia Chen  2 , Zengwu Shao  1 , Zhicai Zhang  1
Affiliations
Review

Animal models of cancer metastasis to the bone

Yihan Yu et al. Front Oncol. .

Abstract

Cancer metastasis is a major cause of mortality from several tumors, including those of the breast, prostate, and the thyroid gland. Since bone tissue is one of the most common sites of metastasis, the treatment of bone metastases is crucial for the cure of cancer. Hence, disease models must be developed to understand the process of bone metastasis in order to devise therapies for it. Several translational models of different bone metastatic tumors have been developed, including animal models, cell line injection models, bone implant models, and patient-derived xenograft models. However, a compendium on different bone metastatic cancers is currently not available. Here, we have compiled several animal models derived from current experiments on bone metastasis, mostly involving breast and prostate cancer, to improve the development of preclinical models and promote the treatment of bone metastasis.

Keywords: animal models; bone metastases; breast cancer; cell lines; prostate cancer.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic of basic bone metastases animal models methods.
See this image and copyright information in PMC

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