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Case Reports
. 2023 Apr 19;10(4):e00999.
doi: 10.14309/crj.0000000000000999. eCollection 2023 Apr.

Hepatic Amyloidosis With Multiorgan Involvement

Robert J Duve  1 , Tiberiu G Moga  2 , Kevin Yang  1 , Thomas C Mahl  2   3 , Eric Dove  4
Affiliations
Case Reports

Hepatic Amyloidosis With Multiorgan Involvement

Robert J Duve et al. ACG Case Rep J. .

Abstract

Amyloidosis is a diverse entity that poses both diagnostic and treatment challenges. Whether systemic or local, amyloidosis has varied manifestations including occasional hepatic involvement. Hepatic amyloidosis, although rare, should be on the differential for those with unexplained hepatomegaly, cholestasis, alkaline phosphatase elevations, other associated organomegaly, and those with certain epidemiologic risks. In this study, we report a case of a man with systemic amyloid light chain amyloidosis with multiorgan involvement, acute liver injury, cholestasis, nephrotic syndrome, cardiomegaly, and bleeding diathesis.

Keywords: AL amyloid; acute liver failure; hepatic; light-chain; ight chain amyloidosis.

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Figures

Figure 1.
Figure 1.
Hematoxylin and eosin section of renal biopsy specimen 40×.
Figure 2.
Figure 2.
Hematoxylin and eosin section of renal biopsy specimen 40×.
Figure 3.
Figure 3.
Renal biopsy specimen staining positive for Congo Red 100×.
Figure 4.
Figure 4.
Renal biopsy specimen staining positive for Congo Red 100×.
See this image and copyright information in PMC

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