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. 2023 Apr 3;7(2):rkad035.
doi: 10.1093/rap/rkad035. eCollection 2023.

The impact of comorbidities on interleukin-17 inhibitor therapy in psoriatic arthritis: a Danish population-based cohort study

Magnus B Petersen  1 , Rebekka L Hansen  1 , Alexander Egeberg  2 , Tanja S Jørgensen  1   3 , Joseph Frank Merola  4 , Laura C Coates  5 , Lars Erik Kristensen  1
Affiliations

The impact of comorbidities on interleukin-17 inhibitor therapy in psoriatic arthritis: a Danish population-based cohort study

Magnus B Petersen et al. Rheumatol Adv Pract. .

Abstract

Objective: To investigate the influence of comorbidities on treatment response, disease activity and persistence with first-line IL-17 inhibitor (IL-17i) treatment in patients with PsA.

Methods: Patients were divided into three groups depending on the presence and/or severity of comorbidities using the Charlson Comorbidity Index (CCI). Groups were CCI 0: no comorbidities, CCI 1: one comorbidity and CCI ≥2: two or more comorbidities or one or more severe comorbidities. Outcomes in the groups were compared for treatment persistence, treatment response and disease activity.

Results: A higher CCI score was associated to an elevation in baseline CRP, swollen joint count and frequency of depression and/or anxiety. The median drug persistence in the groups were CCI 0: 1.8 years, CCI 1: 1.9 years and CCI ≥2: 1.5 years, but was not statistically significant to the CCI score. There were no significant differences in clinical response rates between the groups.

Conclusion: The presence of comorbidities was associated with increased baseline disease activity and frequency of depression and/or anxiety, but was not associated with shorter treatment persistence or lower clinical response rates in a cohort of 155 Danish patients with PsA treated with first-line IL-17i.

Keywords: IL-17 inhibitor; PsA; comorbidities; disease activity; treatment persistence; treatment response.

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Figures

Figure 1.
Figure 1.
Kaplan–Meier plot of IL-17i persistence in patients with CCI scores of 0, 1 or ≥2
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