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Case Reports
. 2023 Apr 6:14:1178247.
doi: 10.3389/fpsyt.2023.1178247. eCollection 2023.

A rare case of schizophrenia coexistence with antiphospholipid syndrome, β-thalassemia, and monoclonal gammopathy of undetermined significance

Yingming Jin  1 , Yiquan Cheng  1 , Jifeng Mi  2 , Jianfen Xu  1
Affiliations
Case Reports

A rare case of schizophrenia coexistence with antiphospholipid syndrome, β-thalassemia, and monoclonal gammopathy of undetermined significance

Yingming Jin et al. Front Psychiatry. .

Abstract

A patient with schizophrenia who was treated with chlorpromazine developed lupus anticoagulant (LA) and antiphospholipid syndrome (APS). On protein electrophoresis, a monoclonal immunoglobulin A peak was seen in this patient, defining a condition of monoclonal gammopathy of undetermined significance. Additionally, β-thalassemia was diagnosed with the CD41-42 genotype. This condition is extremely rare, particularly in patients with schizophrenia and APS. We present a case of a patient with schizophrenia and secondary APS who had a positive LA, a significantly prolonged activated partial thromboplastin time, endogenous coagulation factor deficiency and inhibitor, no bleeding, and an unexpected finding of β-thalassemia and monoclonal IgA. Following that, a literature review on the disorders was presented.

Keywords: MGUS; antiphospholipid syndrome; chlorpromazine; lupus anticoagulant; schizophrenia; β-thalassemia.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Serum electrophoresis and immunofixation electrophoresis of the patient.
See this image and copyright information in PMC

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