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. 2023 Apr 3:11:1164681.
doi: 10.3389/fcell.2023.1164681. eCollection 2023.

Autosis as a selective type of cell death

Lingge Bai  1 , Qiong Wu  1 , Xinyue Zhang  1 , Yuting Zhao  1
Affiliations

Autosis as a selective type of cell death

Lingge Bai et al. Front Cell Dev Biol. .

Erratum in

No abstract available

Keywords: Beclin 1; Na+/K+-ATPase; Tat-BECN1 peptide; autophagic cell death; autophagy; autosis; cardiac glycosides.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) Selectivity of autosis. During renal ischemia/reperfusion, pericytes undergo autosis (with morphological features such as focal swelling of the perinuclear space), but not tubular cells or endothelial cells. Upon treatment with Tat-BECN1 peptide or other autosis inducers, HIV-1-infected cells (macrophages or CD4+ T cells) undergo autosis, but not uninfected cells. Upon treatment with Tat-BECN1 peptide or other autosis inducers, or oncolytic virus-infected CAR-T cells, tumor cells undergo autosis, but not non-tumor cells. (B) Regulation of autosis. Class III PI3K complexes and Na+/K+-ATPase are two major mediators of autosis, which interact through Beclin 1 and alpha subunits. Pharmacologically, the interaction is enhanced by autosis inducer Tat-BECN1 peptide and blocked by autosis inhibitor cardiac glycosides. Regulatory proteins of autosis act on Class III PI3K complexes by 1) transcriptional regulation, 2) post-translational modifications, and 3) protein–protein interactions. Autosis occurs in vivo, in the brain during cerebral hypoxia/ischemia, in the kidney during renal ischemia/reperfusion, in the heart during cardiac ischemia/reperfusion, in the liver during anorexia nervosa, and in the skin during terminal differentiation of keratinocyte lineage cells.
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References

    1. Akimoto M., Iizuka M., Kanematsu R., Yoshida M., Takenaga K. (2015). Anticancer effect of ginger extract against pancreatic cancer cells mainly through reactive oxygen species-mediated autotic cell death. PLoS One 10 (5), e0126605. 10.1371/journal.pone.0126605 - DOI - PMC - PubMed
    1. Cabrera-Rodriguez R., Perez-Yanes S., Estevez-Herrera J., Marquez-Arce D., Cabrera C., Espert L., et al. (2021). The interplay of HIV and autophagy in early infection. Front. Microbiol. 12, 661446. 10.3389/fmicb.2021.661446 - DOI - PMC - PubMed
    1. Camuzard O., Trojani M. C., Santucci-Darmanin S., Pagnotta S., Breuil V., Carle G., et al. (2020). Autophagy in osteosarcoma cancer stem cells is critical process which can Be targeted by the antipsychotic drug thioridazine. Cancers (Basel) 12 (12), 3675. 10.3390/cancers12123675 - DOI - PMC - PubMed
    1. Chang C., Young L. N., Morris K. L., von Bulow S., Schoneberg J., Yamamoto-Imoto H., et al. (2019). Bidirectional control of autophagy by BECN1 BARA domain dynamics. Mol. Cell 73 (2), 339–353 e6. 10.1016/j.molcel.2018.10.035 - DOI - PMC - PubMed
    1. Chen Y., Henson E. S., Xiao W., Huang D., McMillan-Ward E. M., Israels S. J., et al. (2016). Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia. Autophagy 12 (6), 1029–1046. 10.1080/15548627.2016.1164357 - DOI - PMC - PubMed

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