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. 2022 Dec;22(4):70-76.
doi: 10.4314/ahs.v22i4.10.

Bloodstream infection in cancer patients; susceptibility profiles of the isolated pathogens, at Khartoum Oncology Hospital, Sudan

Omeima Mohammed Zain  1 , Mohimmen Yousif Elsayed  1 , Sozan M Abdelkhalig  2 , Manal Abdelaziz  3 , Safaa Yahia Ibrahim  4 , Tahane Bashir  5 , Yassir Hamadalnil  6
Affiliations

Bloodstream infection in cancer patients; susceptibility profiles of the isolated pathogens, at Khartoum Oncology Hospital, Sudan

Omeima Mohammed Zain et al. Afr Health Sci. 2022 Dec.

Abstract

Introduction: Bloodstream infection is one of the major causes of mortality in patients with malignancies. This study aimed to determine the local profile of blood culture isolates and their antibiotic sensitivities in febrile neutropenic cancer patients and to decide if any modifications to antibiotics policies are necessary.

Methods: This is a cross-sectional study conducted between the first of October to the end of December 2018 at Khartoum Oncology Hospital, Sudan. Blood samples from febrile neutropenic patients were collected for culture. Isolates were identified, and their antimicrobial susceptibility was determined by standard laboratory procedures.

Results: Bloodstream infections were confirmed in 12 % (n = 69/569) of total blood cultures. Gram negative bacilli were the dominant causative agents (63.8%) while (36.2%) of infections were caused by gram positive cocci. Escherichia coli was the most common isolate (30.4%).The proportions of resistance among gram negative bacilli were high for cefuroxime, amoxicillin/clavulanic acid, Ceftazidime, and ceftriaxone. Extended-spectrum β-lactamase producing isolates were identified in 34.1% of the positive cultures. Gram positive cocci showed high resistance to tetracycline, penicillin and erythromycin but were completely sensitive to vancomycin and gentamicin. Most of Staphylococcus aureus isolates were methicillin resistant.

Conclusion: Gram negative bacilli were the predominant etiologic agents of bloodstream infections in our patients. Both Gram-positive and Gram-negative bacteria showed high levels of resistance for most of the common antibiotics used for empiric treatment. Regular surveillance to study bacterial resistance patterns must be conducted to modify antibiotics stewardship in our institution.

Keywords: Blood stream infection; Sudan; antibiotics sensitivity; malignancy.

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Conflict of interest statement

The authors declare no competing interest.

Figures

Figure 1
Figure 1
Distribution of Bacterial Isolates from the 69 Positive Blood Samples
Figure 2
Figure 2
Antibiotic Susceptibility of the Gram-negative Isolates
See this image and copyright information in PMC

References

    1. Friedman H, Specter S, Watanabe M, Pan SH. Tumor-induced immunosuppression. Am J Pathol. 1978;93(2):499–513. - PMC - PubMed
    1. Gudiol C, Aguado JM, Carratalà J. Bloodstream infections in patients with solid tumors. Virulence. 2016;7(3):298–308. - PMC - PubMed
    1. Montassier E, Batard E, Gastinne T, Potel G, de La Cochetière MF. Recent changes in bacteremia in patients with cancer: a systematic review of epidemiology and antibiotic resistance. Eur J Clin Microbiol Infect Dis. 2013 Jul;32(7):841–850. - PubMed
    1. Walshe LJ, Malak SF, Eagan J, Sepkowitz KA. Complication rates among cancer patients with peripherally inserted central catheters. J Clin Oncol. 2002;20(15):3276–3281. - PubMed
    1. Park K, Jun HJ, Oh SY. Safety, efficacy, and patient-perceived satisfaction of peripherally inserted central catheters in terminally ill cancer patients: a prospective multicenter observational study. Support Care Cancer. 2016;24(12):4987–4992. - PubMed

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