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. 2023 Apr 6;9(2):20.
doi: 10.3390/ijns9020020.

Implementation of Newborn Screening for Conditions in the United States First Recommended during 2010-2018

Sikha Singh  1 , Jelili Ojodu  1 , Alex R Kemper  2 , Wendy K K Lam  3 , Scott D Grosse  4
Affiliations

Implementation of Newborn Screening for Conditions in the United States First Recommended during 2010-2018

Sikha Singh et al. Int J Neonatal Screen. .

Abstract

The Recommended Uniform Screening Panel (RUSP) is the list of conditions recommended by the US Secretary of Health and Human Services for inclusion in state newborn screening (NBS). During 2010-2022, seven conditions were added to the RUSP: severe combined immunodeficiency (SCID) (2010), critical congenital heart disease (CCHD) (2011), glycogen storage disease, type II (Pompe) (2015), mucopolysaccharidosis, type I (MPS I) (2016), X-linked adrenoleukodystrophy (X-ALD) (2016), spinal muscular atrophy (SMA) (2018), and mucopolysaccharidosis, type II (MPS II) (2022). The adoption of SCID and CCHD newborn screening by programs in all 50 states and three territories (Washington, D.C.; Guam; and Puerto Rico) took 8.6 and 6.8 years, respectively. As of December 2022, 37 programs screen for Pompe, 34 for MPS I, 32 for X-ALD, and 48 for SMA. The pace of implementation based on the average additional number of NBS programs per year was most rapid for SMA (11.3), followed by CCHD (7.8), SCID (6.2), MPS I (5.4), Pompe (4.9), and X-ALD (4.7).

Keywords: new conditions; newborn screening; public health.

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Conflict of interest statement

The authors declare they have no conflict of competing interest.

Figures

Figure 1
Figure 1
Average Number of Years to Implementation of Conditions Added to RUSP during 2010–2018 for Programs that Completed Implementation by 2022.
Figure 2
Figure 2
Number of Programs Implementing Screening Each Year for SCID (n = 53), CCHD (n = 53), Pompe (n = 37), MPS I (n = 34), X-ALD (n = 32), and SMA (n = 48) as of December 2022 (marker indicates year of addition to RUSP).
See this image and copyright information in PMC

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