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Review
. 2023 Jun 1;34(3):126-132.
doi: 10.1097/MOL.0000000000000880. Epub 2023 Mar 28.

Assessment of atherosclerosis: should coronary calcium score and intima-media thickness be replaced by ultrasound measurement of carotid plaque burden and vessel wall volume?

J David Spence  1
Affiliations
Review

Assessment of atherosclerosis: should coronary calcium score and intima-media thickness be replaced by ultrasound measurement of carotid plaque burden and vessel wall volume?

J David Spence. Curr Opin Lipidol. .

Abstract

Purpose of review: To describe the uses of vessel wall volume (VWV) and measurement of carotid plaque burden, as total plaque area (TPA) and total plaque volume (TPV), and to contrast them with measurement of carotid intima-media thickness (IMT) and coronary calcium (CAC).

Recent findings: Measurement of carotid plaque burden (CPB) is useful for risk stratification, research into the genetics and biology of atherosclerosis, for measuring effects of new therapies for atherosclerosis, and for treatment of high-risk patients with severe atherosclerosis. It is as predictive of risk as CAC, with important advantages. IMT is only a weak predictor of risk and changes so little over time that it is not useful for assessing effects of therapy.

Summary: Measurement of CPB and VWV are far superior to measurement of carotid IMT in many ways, and should replace it. Vessel wall volume can be measured in persons with no plaque as an alternative to IMT. There are important advantages of CPB over coronary calcium; CPB should be more widely used in vascular prevention.

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References

    1. Spence JD. Measurement of carotid plaque burden. Curr Opin Lipidol 2020; 31:291–298.
    1. Spence JD, Hackam DG. Treating arteries instead of risk factors. A paradigm change in management of atherosclerosis. Stroke 2010; 41:1193–1199.
    1. Bond MG, Wilmoth SK, Gardin JF, et al. Noninvasive assessment of atherosclerosis in nonhuman primates. Adv Exp Med Biol 1985; 183:189–195.
    1. Baldassarre D, Werba JP, Tremoli E, et al. Common carotid intima-media thickness measurement. A method to improve accuracy and precision. Stroke 1994; 25:1588–1592.
    1. Pignoli P, Tremoli E, Poli A, et al. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 1986; 74:1399–1406.