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. 1986 Mar:65:243-8.
doi: 10.1289/ehp.8665243.

Effects of phthalic acid esters (PAEs) on the neonate and aspects of teratogenic actions

J A Thomas, D B Wienckowski, B A Gillies, M J Thomas, E J Youkilis

Effects of phthalic acid esters (PAEs) on the neonate and aspects of teratogenic actions

J A Thomas et al. Environ Health Perspect. 1986 Mar.

Abstract

A review of the literature reveals that several different phthalic acid esters (PAEs) are capable of causing testicular damage. Phthalate-induced zinc deficiency is consistent with germinal epithelial damage. Among experimental animals, mice perhaps show the greatest sensitivity to phthalate-induced terata, but high doses/exposure are required. Little toxicologic information is available with regard to phthalate-induced effects upon the neonate.

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References

    1. J Pharm Sci. 1966 Feb;55(2):158-62 - PubMed
    1. J Environ Pathol Toxicol. 1980 Sep;4(2-3):533-44 - PubMed
    1. Ann N Y Acad Sci. 1969;160(1):334-43 - PubMed
    1. Gig Sanit. 1970 Jan;35(1):105-6 - PubMed
    1. J Pharmacol Exp Ther. 1970 Feb;171(2):314-24 - PubMed

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