Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1986 Mar:65:39-43.
doi: 10.1289/ehp.866539.

Cadmium-binding proteins in the mussel, Mytilus edulis

Comparative Study

Cadmium-binding proteins in the mussel, Mytilus edulis

J M Frazier. Environ Health Perspect. 1986 Mar.

Abstract

Inducible cadmium-binding proteins (Cd-BP) in the mussel, Mytilus edulis, were resolved into two molecular weight components, designated Cd-BP10 and Cd-BP20, by gel-permeation chromatography on Sephadex G-75. Each of these two molecular weight components were further resolved into four subcomponents by DEAE-ion-exchange chromatography. All eight subcomponents bound cadmium and exhibited significant UV absorption at 254 nm and little absorption at 280 nm. Each subcomponent was purified and subjected to amino acid composition analysis. Two classes were identified, one having higher cysteine (23.9-26.6 mole-%) and lower glutamic acid contents compared to the other class (11.6-18.2 mole-% cysteine). All subcomponents have a relatively high glycine content (approximately 15 mole-%) relative to mammalian metallothioneins (approximately 8 mole-%). Although the Cd-BP20 have apparent molecular weights almost twice the Cd-BP10, the exact molecular relationship between these binding proteins is not known.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Biol Chem. 1974 Jun 10;249(11):3537-42 - PubMed
    1. Comp Biochem Physiol C. 1980;67C(2):215-8 - PubMed
    1. Arch Environ Contam Toxicol. 1978;7(1):73-81 - PubMed
    1. FEBS Lett. 1977 Oct 15;82(2):247-50 - PubMed

Publication types

LinkOut - more resources