Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT)

Mohamad Mohty^#¹, Florent Malard^#², Ahmed S Alaskar^#³, Mahmoud Aljurf^#⁴, Mutlu Arat^#⁵, Peter Bader^#⁶, Frederic Baron^#⁷, Ali Bazarbachi^#⁸, Didier Blaise^#⁹, Eolia Brissot^#², Fabio Ciceri^#¹⁰, Selim Corbacioglu^#¹¹, Jean-Hugues Dalle^#¹², Fiona Dignan^#¹³, Anne Huynh^#¹⁴, Michelle Kenyon^#¹⁵, Arnon Nagler^#¹⁶, Antonio Pagliuca^#¹⁵, Zinaida Perić^#¹⁷, Paul G Richardson^#¹⁸, Annalisa Ruggeri^#¹⁰, Tapani Ruutu^#¹⁹, Ibrahim Yakoub-Agha^#²⁰, Rafael F Duarte^#²¹, Enric Carreras^#²²

Affiliations

¹ Hematology Department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France. mohamad.mohty@inserm.fr.
² Hematology Department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France.
³ King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Dept. of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
⁴ King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
⁵ Sisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
⁶ Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
⁷ Department of Hematology, University of Liege, Liege, Belgium.
⁸ Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
⁹ Aix-Marseille Univ, MSC Lab, Institut Paoli-Calmettes, Department of Hematology, Marseille, France.
¹⁰ San Raffaele Scientific Institute, Hematology and Bone marrow Transplantation Unit, Milan, Italy.
¹¹ Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
¹² Department of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
¹³ Department of Clinical Haematology, Manchester University NHS Foundation Trust, Manchester, UK.
¹⁴ Hematology Department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
¹⁵ Department of Haematology, King's College Hospital, London, UK.
¹⁶ Hematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
¹⁷ Department of Hematology, University Hospital Centre Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia.
¹⁸ Division of Hematology, Mayo Clinic, Rochester, MN, USA.
¹⁹ Clinical Research Institute, Helsinki University Hospital, Helsinki, Finland.
²⁰ CHU de Lille, Univ Lille, INSERM U1286, Infinite, 59000, Lille, France.
²¹ Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
²² Josep Carreras Foundation & Leukemia Research Institute, (Hospital Clínic/Barcelona University Campus), Barcelona, Spain.

^# Contributed equally.

PMID: 37095231
DOI: 10.1038/s41409-023-01992-8

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Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT)

Mohamad Mohty et al. Bone Marrow Transplant. 2023 Jul.

Free article

. 2023 Jul;58(7):749-754.

doi: 10.1038/s41409-023-01992-8. Epub 2023 Apr 24.

Authors

Affiliations

¹ Hematology Department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France. mohamad.mohty@inserm.fr.
² Hematology Department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France.
³ King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Dept. of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
⁴ King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
⁵ Sisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
⁶ Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
⁷ Department of Hematology, University of Liege, Liege, Belgium.
⁸ Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
⁹ Aix-Marseille Univ, MSC Lab, Institut Paoli-Calmettes, Department of Hematology, Marseille, France.
¹⁰ San Raffaele Scientific Institute, Hematology and Bone marrow Transplantation Unit, Milan, Italy.
¹¹ Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
¹² Department of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
¹³ Department of Clinical Haematology, Manchester University NHS Foundation Trust, Manchester, UK.
¹⁴ Hematology Department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
¹⁵ Department of Haematology, King's College Hospital, London, UK.
¹⁶ Hematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
¹⁷ Department of Hematology, University Hospital Centre Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia.
¹⁸ Division of Hematology, Mayo Clinic, Rochester, MN, USA.
¹⁹ Clinical Research Institute, Helsinki University Hospital, Helsinki, Finland.
²⁰ CHU de Lille, Univ Lille, INSERM U1286, Infinite, 59000, Lille, France.
²¹ Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
²² Josep Carreras Foundation & Leukemia Research Institute, (Hospital Clínic/Barcelona University Campus), Barcelona, Spain.

^# Contributed equally.

PMID: 37095231
DOI: 10.1038/s41409-023-01992-8

Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). A new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, was reported a few years ago on behalf of the European Society for Blood and Marrow Transplantation (EBMT). The aim of this work is to update knowledge regarding diagnosis and severity assessment of SOS/VOD in adult patients, and also its pathophysiology and treatment. In particular, we now propose to refine the previous classification and distinguish probable, clinical and proven SOS/VOD at diagnosis. We also provide an accurate definition of multiorgan dysfunction (MOD) for SOS/VOD severity grading based on Sequential Organ Failure Assessment (SOFA) score.

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References

1. Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M et al. Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European society for blood and marrow transplantation (EBMT). Bone Marrow Transpl. 2015; https://doi.org/10.1038/bmt.2015.52 .
1. Coppell JA, Richardson PG, Soiffer R, Martin PL, Kernan NA, Chen A, et al. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant: J Am Soc Blood Marrow Transplant. 2010;16:157–68. https://doi.org/10.1016/j.bbmt.2009.08.024 . - DOI
1. Richardson PG, Riches ML, Kernan NA, Brochstein JA, Mineishi S, Termuhlen AM et al. Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. Blood. 2016; https://doi.org/10.1182/blood-2015-10-676924 .
1. Carreras E, Bertz H, Arcese W, Vernant JP, Tomas JF, Hagglund H, et al. Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European group for blood and marrow transplantation. Euro Group Blood Marrow Transpl Chronic Leuk Working Party. Blood. 1998;92:3599–604. - PubMed
1. Carreras E, Diaz-Beya M, Rosinol L, Martinez C, Fernandez-Aviles F, Rovira M. The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade. Biol Blood Marrow Transpl. 2011;17:1713–20. https://doi.org/10.1016/j.bbmt.2011.06.006 . - DOI

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Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT)

Affiliations

Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT)

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical