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Review
. 2023 Oct;25(10):2812-2831.
doi: 10.1007/s12094-023-03163-z. Epub 2023 Apr 24.

Emerging roles of long non-coding RNA FTX in human disorders

Mohadeseh Sheykhi-Sabzehpoush  1 , Majid Ghasemian  2 , Fatemeh Khojasteh Pour  3 , Mohammad Mighani  4 , Mehdi Moghanibashi  5 , Razieh Mohammad Jafari  6 , Maciej Zabel  7   8 , Piotr Dzięgiel  8 , Maryam Farzaneh  9 , Bartosz Kempisty  10   11   12
Affiliations
Review

Emerging roles of long non-coding RNA FTX in human disorders

Mohadeseh Sheykhi-Sabzehpoush et al. Clin Transl Oncol. 2023 Oct.

Abstract

Long non-coding RNAs (lncRNAs) are involved the progression of cancerous and non-cancerous disorders via different mechanism. FTX (five prime to xist) is an evolutionarily conserved lncRNA that is located upstream of XIST and regulates its expression. FTX participates in progression of various malignancy including gastric cancer, glioma, ovarian cancer, pancreatic cancer, and retinoblastoma. Also, FTX can be involved in the pathogenesis of non-cancerous disorders such as endometriosis and stroke. FTX acts as competitive endogenous RNA (ceRNA) and via sponging various miRNAs, including miR-186, miR-200a-3p, miR-215-3p, and miR-153-3p to regulate the expression of their downstream target. FTX by targeting various signaling pathways including Wnt/β-catenin, PI3K/Akt, SOX4, PDK1/PKB/GSK-3β, TGF-β1, FOXA2, and PPARγ regulate molecular mechanism involved in various disorders. Dysregulation of FTX is associated with an increased risk of various disorders. Therefore, FTX and its downstream targets may be suitable biomarkers for the diagnosis and treatment of human malignancies. In this review, we summarized the emerging roles of FTX in human cancerous and non-cancerous cells.

Keywords: Biomarkers; Cancer; FTX; LncRNAs; miRNAs.

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References

    1. Gu L, Li Q, Liu H, Lu X, Zhu M. Long noncoding RNA TUG1 promotes autophagy-associated paclitaxel resistance by sponging miR-29b-3p in ovarian cancer cells. Onco Targets Ther. 2007;2020:13.
    1. Jiang MC, Ni JJ, Cui WY, Wang BY, Zhuo W. Emerging roles of lncRNA in cancer and therapeutic opportunities. Am J Cancer Res. 2019;9:1354–66. - PubMed - PMC
    1. Farzaneh M, Ghasemian M, Ghaedrahmati F, Poodineh J, Najafi S, Masoodi T, et al. Functional roles of lncRN-TUG1 in hepatocellular carcinoma. Life Sci. 2022;308:120974. - PubMed - DOI
    1. Xu W-W, Jin J, Wu X-y, Ren Q-L, Farzaneh M. MALAT1-related signaling pathways in colorectal cancer. Cancer Cell Int. 2022;22:1–9. - PubMed - PMC - DOI
    1. Ghasemian M, Rajabibazl M, Sahebi U, Sadeghi S, Maleki R, Hashemnia V, et al. Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders. Cancer Cell Int. 2022;22:1–12. - DOI

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