Sputum IL-6 level as a potential predictor of acute chest syndrome during vaso-occlusive crisis in children with sickle cell disease: Exploratory prospective prognostic accuracy study

Slimane Allali^{1

2

3}, Juliette Elie^{1

2}, Lara Mayrand^{1

2}, Mariane de Montalembert^{1

3}, Melissa Taylor^{1

3}, Joséphine Brice^{1

3}, Amandine Maire¹, Rachel Rignault-Bricard^{2

3}, Claire Heilbronner⁴, Jérémie F Cohen^{1

5}, Thiago T Maciel^{2

3}, Olivier Hermine^{2

3

6}

Affiliations

¹ Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
² Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Université Paris Cité, Imagine Institute, Inserm U1163, Paris, France.
³ Laboratory of Excellence GR-Ex, Paris, France.
⁴ Department of Pediatric Intensive care, Necker-Enfants malades Hospital, AP-HP, Université Paris Cité, Paris, France.
⁵ Centre of Research in Epidemiology and Statistics-CRESS, INSERM, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France.
⁶ Department of Hematology, Necker-Enfants malades Hospital, AP-HP, Université Paris Cité, Paris, France.

Free article

Slimane Allali et al. Am J Hematol. 2023 Jul.

Free article

. 2023 Jul;98(7):E175-E178.

doi: 10.1002/ajh.26939. Epub 2023 Apr 25.

¹ Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
² Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Université Paris Cité, Imagine Institute, Inserm U1163, Paris, France.
³ Laboratory of Excellence GR-Ex, Paris, France.
⁴ Department of Pediatric Intensive care, Necker-Enfants malades Hospital, AP-HP, Université Paris Cité, Paris, France.
⁵ Centre of Research in Epidemiology and Statistics-CRESS, INSERM, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France.
⁶ Department of Hematology, Necker-Enfants malades Hospital, AP-HP, Université Paris Cité, Paris, France.

No abstract available

References

1. Bartolucci P, Habibi A, Khellaf M, et al. Score predicting acute chest syndrome during Vaso-occlusive crises in adult sickle-cell disease patients. EBioMedicine. 2016;10:305-311.
1. Styles L, Wager CG, Labotka RJ, et al. Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: results of a feasibility study (PROACTIVE). Br J Haematol. 2012;157(5):627-636.
1. Allali S, de Montalembert M, Rignault-Bricard R, et al. IL-6 levels are dramatically high in the sputum from children with sickle cell disease during acute chest syndrome. Blood Adv. 2020;4(24):6130-6134.
1. Allali S, Chhun S, de Montalembert M, et al. Tocilizumab for severe acute chest syndrome in a child with sickle cell disease and dramatically high IL-6 values in endotracheal and pleural fluids. Am J Hematol. 2022;97(3):E81-E83.
1. Al Biltagi M, Bediwy AS, Toema O, Al-Asy HM, Saeed NK. Pulmonary functions in children and adolescents with sickle cell disease. Pediatr Pulmonol. 2020;55(8):2055-2063.