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. 1986 Mar 18;122(2):269-73.
doi: 10.1016/0014-2999(86)90112-3.

Muscarine binding sites in bovine adrenal medulla

B A Barron, L C Murrin, T D Hexum

Muscarine binding sites in bovine adrenal medulla

B A Barron et al. Eur J Pharmacol. .

Abstract

The presence of muscarinic binding sites in the bovine adrenal medulla was investigated using [3H]QNB and the bovine adrenal medulla. Scatchard analysis combined with computer analysis yielded data consistent with a two binding site configuration. KDs of 0.15 and 14 nM and Bmax s of 29 and 210 fmol/mg protein, respectively, were observed. Displacement of [3H]QNB by various cholinergic agents is, in order of decreasing potency: QNB, dexetimide, atropine, scopolamine, imipramine, desipramine, oxotremorine, pilocarpine, acetylcholine, methacholine and carbachol. These results demonstrate the presence of more than one muscarine binding site in the bovine adrenal gland.

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