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. 2023 May;35(5):e14543.
doi: 10.1111/nmo.14543. Epub 2023 Feb 27.

Clinical utility of colonic low-amplitude propagating contractions in children with functional constipation

Kitzia Colliard  1 , Dhiren Patel  2 , Samuel Nurko  1 , Leonel Rodriguez  1   3
Affiliations

Clinical utility of colonic low-amplitude propagating contractions in children with functional constipation

Kitzia Colliard et al. Neurogastroenterol Motil. 2023 May.

Abstract

Background: Colonic high-amplitude propagating contractions (HAPC) are generally accepted as a marker of neuromuscular integrity. Little is known about low-amplitude propagating contractions (LAPCs); we evaluated their clinical utility in children.

Methods: Retrospective review of children with functional constipation undergoing low-resolution colon manometry (CM) recording HAPCs and LAPCs (physiologic or bisacodyl-induced) in three groups: constipation, antegrade colonic enemas (ACE), and ileostomy. Outcome (therapy response) was compared to LAPCs in all patients and within groups. We evaluated LAPCs as potentially representing failed HAPCs.

Key results: A total of 445 patients were included (median age 9.0 years, 54% female), 73 had LAPCs. We found no association between LAPCs and outcome (all patients, p = 0.121), corroborated by logistic regression and excluding HAPCs. We found an association between physiologic LAPCs and outcome that disappears when excluding HAPCs or controlling with logistic regression. We found no association between outcome and bisacodyl-induced LAPCs or LAPC propagation. We found an association between LAPCs and outcome only in the constipation group that cancels with logistic regression and excluding HAPCs (p = 0.026, 0.062, and 0.243, respectively). We found a higher proportion of patients with LAPCs amongst those with absent or abnormally propagated (absent or partially propagated) HAPCs compared to those with fully propagated HAPCs (p = 0.001 and 0.004, respectively) suggesting LAPCs may represent failed HAPCs.

Conclusions/inferences: LAPCs do not seem to have added clinical significance in pediatric functional constipation; CM interpretation could rely primarily on the presence of HAPCs. LAPCs may represent failed HAPCs. Larger studies are needed to further validate these findings.

Keywords: GI motility; colonic manometry; defecation disorders; functional constipation; functional gastrointestinal disorders; high amplitude propagating contractions; low amplitude propagating contractions; neurogastroenterology and motility; pediatrics.

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