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Editorial
. 2023 Aug 1;129(15):2294-2296.
doi: 10.1002/cncr.34801. Epub 2023 Apr 25.

RNA sequencing steps toward the first line

Theresa A Boyle  1 , Aaron D Bossler  1
Affiliations
Free article
Editorial

RNA sequencing steps toward the first line

Theresa A Boyle et al. Cancer. .
Free article

Abstract

DNA is the sequence that codes for proteins. Messenger RNA is transcribed from the DNA sequence of genes and translated into protein. It can be difficult to predict how a change in the DNA sequence will affect messenger RNA and protein quantity and quality. DNA translocation changes can cause the joining of sequences from two different genes or different parts of the same gene. DNA sequencing is often used clinically to predict how DNA changes might affect proteins. Alternatively, RNA sequencing can be used as a more direct measure of the effect of DNA changes on the protein products. This sequencing is important for identifying changes in cancer that may indicate response to targeted therapy, prognosis, or diagnosis.

Keywords: RNA sequencing; biomarkers; fusion protein; next-generation sequencing (NGS); nonsmall cell lung cancer; splice variant; targeted therapy; translocation.

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