Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct;16(5):1184-1193.
doi: 10.1007/s12265-023-10388-4. Epub 2023 Apr 25.

Isolated Coronary Arteritis in Adults: a Single-Center Experience from China

Lingyu Liu  1 , Jing Li  1 , Tianpeng Gan  2 , Yunjiao Yang  1 , Xinping Tian  3   4   5
Affiliations

Isolated Coronary Arteritis in Adults: a Single-Center Experience from China

Lingyu Liu et al. J Cardiovasc Transl Res. 2023 Oct.

Abstract

Isolated coronary arteritis (ICA) is an extremely rare and life-threatening vasculitis with only a limited number of reports in the literature. We retrospectively reviewed the clinical data of 10 ICA patients in our center from 2012 to 2022 and compared them with patients with Takayasu arteritis who presented with coronary arteritis initially (TAK-CA patients). We found that ICA predominantly affected women and most commonly involved the ostium and the proximal segment of the coronary arteries, causing mainly stenotic lesions. The C-reactive protein and erythrocyte sedimentation rate were grossly normal and significantly lower than those of TAK-CA patients (p = 0.027, p = 0.009, respectively). Intravascular ultrasound imaging showed superiority in differentiating coronary vasculitis from atherosclerosis. Restenosis of the coronary arteries occurred rapidly if not treated promptly and appropriately. Systemic glucocorticoid combined with immunosuppressive agents, especially cyclophosphamide, was a promising strategy for treating ICA.

Keywords: Coronary arteritis; Coronary artery disease; Coronary vasculitis; Single-organ vasculitis.

PubMed Disclaimer

References

    1. Norita K, de Noronha SV, Sheppard MN. Sudden cardiac death caused by coronary vasculitis. Virchows Arch. 2012;460(3):309–18. https://doi.org/10.1007/s00428-011-1173-z . - DOI - PubMed
    1. Vaideeswar P, Verma R, Gupta R. Infective coronary arteritis: a pathological analysis at autopsy. Hum Pathol. 2012;43(12):2334–41. https://doi.org/10.1016/j.humpath.2012.04.005 . - DOI - PubMed
    1. Gori T Coronary vasculitis. Biomedicines (2021);9(6) https://doi.org/10.3390/biomedicines9060622 .
    1. Balink H, Bennink RJ, van Eck-Smit BL, et al. The role of 18F-FDG PET/CT in large-vessel vasculitis: appropriateness of current classification criteria? Biomed Res Int. 2014;2014:687608. https://doi.org/10.1155/2014/687608 . - DOI - PubMed - PMC
    1. Chrapko BE, Chrapko M, Nocuń A, et al. Role of 18F-FDG PET/CT in the diagnosis of inflammatory and infectious vascular disease. Nucl Med Rev Cent East Eur. 2016;19(1):28–36. https://doi.org/10.5603/nmr.2016.0006 . - DOI - PubMed

Publication types

LinkOut - more resources