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Meta-Analysis
. 2023 Apr 25:25:e42090.
doi: 10.2196/42090.

The Efficacy and Safety of Telerehabilitation for Fibromyalgia: Systematic Review and Meta-analysis of Randomized Controlled Trials

Yong-Qiang Wu  1 , Yi Long  1 , Wei-Jie Peng  1 , Cheng Gong  1 , Yue-Quan Liu  2 , Xu-Miao Peng  1 , Yan-Biao Zhong #  2 , Yun Luo #  2 , Mao-Yuan Wang #  2
Affiliations
Meta-Analysis

The Efficacy and Safety of Telerehabilitation for Fibromyalgia: Systematic Review and Meta-analysis of Randomized Controlled Trials

Yong-Qiang Wu et al. J Med Internet Res. .

Abstract

Background: Fibromyalgia is a chronic pain syndrome characterized by persistent and widespread musculoskeletal pain. Telerehabilitation is a promising treatment for patients with fibromyalgia through long-term monitoring, intervention, supervision, consultation, and education.

Objective: This study aimed to perform a comprehensive systematic review and meta-analysis of the efficacy and safety of telerehabilitation in patients with fibromyalgia.

Methods: Randomized controlled trials (RCTs) related to fibromyalgia and telerehabilitation were systematically searched in the PubMed, PEDro, Cochrane Library, ScienceDirect, Ovid MEDLINE, Embase, and Web of Science databases from inception to November 13, 2022. Two independent researchers screened the literatures and evaluated the methodological quality using the Cochrane Risk of Bias Tool. The outcome measures included the Fibromyalgia Impact Questionnaire scale, pain intensity, depression, pain catastrophizing, quality of life (QoL), and adverse events. Pooled effect sizes were calculated by Stata SE 15.1; a fixed effects model was used when I2<50%, whereas a random effects model was used when I2≥50%.

Results: A total of 14 RCTs with 1242 participants were included in this meta-analysis. The pooled results indicated that the telerehabilitation improved the Fibromyalgia Impact Questionnaire score (weighted mean difference -8.32, 95% CI -11.72 to -4.91; P<.001), pain intensity (standardized mean difference [SMD] -0.62, 95% CI -0.76 to -0.47; P<.001), depression levels (SMD -0.42, 95% CI -0.62 to -0.22; P<.001), pain catastrophizing (weighted mean difference -5.81, 95% CI -9.40 to -2.23; P=.001), and QoL (SMD 0.32, 95% CI 0.18 to 0.47; P<.001) in patients with fibromyalgia compared to control interventions. Only 1 RCT reported a mild adverse event of telerehabilitation; the other 13 RCTs did not mention this.

Conclusions: Telerehabilitation can improve the symptoms and QoL of fibromyalgia. However, the safety of telerehabilitation remains uncertain due to the lack of sufficient evidence for the management of fibromyalgia. More rigorously designed trials are needed in the future to verify the safety and efficacy of telerehabilitation in fibromyalgia.

Trial registration: PROSPERO CRD42022338200; https://tinyurl.com/322keukv.

Keywords: chronic pain; consultation; education; efficacy; fibromyalgia; intervention; meta-analysis; monitoring; musculoskeletal; pain; rehabilitation; safety; systematic review; telerehabilitation.

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Conflict of interest statement

Conflicts of Interest: None declared.

Figures

Figure 1
Figure 1
Flowchart of study selection. RCT: randomized controlled trial.
Figure 2
Figure 2
Risk of bias summary: review authors’ judgements about each risk of bias item for each included study [18-21,27-36].
Figure 3
Figure 3
Risk of bias graph: review authors’ judgements about each risk of bias item presented as percentages across all included studies.
Figure 4
Figure 4
The effect of telerehabilitation on the Fibromyalgia Impact Questionnaire scale in fibromyalgia. WMD: weighted mean difference.
Figure 5
Figure 5
The effect of telerehabilitation on pain intensity in fibromyalgia. SMD: standardized mean difference.
Figure 6
Figure 6
The effect of telerehabilitation on depression in fibromyalgia. SMD: standardized mean difference.
Figure 7
Figure 7
The effect of telerehabilitation on pain catastrophizing in fibromyalgia. WMD: weighted mean difference.
Figure 8
Figure 8
The effect of telerehabilitation on the quality of life in fibromyalgia. SMD: standardized mean difference.
See this image and copyright information in PMC

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