doi: 10.1016/0014-2999(79)90202-4.
Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors
- PMID: 37098
- DOI: 10.1016/0014-2999(79)90202-4
Item in Clipboard
Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors
Eur J Pharmacol.
.
Abstract
3H-Prazosin binding to membranes from rat brain is saturable, Bmax, 77 fmol/mg protein, of high affinity, KD, 0.28 nM and with a drug specificity indicating that it labels alpha-adrenergic receptors. The ranking of alpha-antagonists for these binding sites suggests that 3H-prazosin may be useful in identifying a subpopulation of alpha-receptors (alpha1) in the central nervous system.
Similar articles
-
Characteristics of [3H]E-643-binding to alpha adrenoceptors.Jpn J Pharmacol. 1982 Feb;32(1):181-7. doi: 10.1254/jjp.32.181. Jpn J Pharmacol. 1982. PMID: 6123609
-
Displacement by alpha-adrenergic agonists and antagonists of 3H-prazosin bound to the alpha-adrenoceptors of the dog aorta and the rat brain.Jpn J Pharmacol. 1985 Feb;37(2):181-7. doi: 10.1254/jjp.37.181. Jpn J Pharmacol. 1985. PMID: 2860265
-
3H-Prazosin binds specifically to 'alpha 1'-adrenoceptors in rat brain.Naunyn Schmiedebergs Arch Pharmacol. 1980 May;312(1):23-6. doi: 10.1007/BF00502569. Naunyn Schmiedebergs Arch Pharmacol. 1980. PMID: 6248797
-
Subclassification of alpha-adrenergic receptors by direct binding studies.Biochem Pharmacol. 1979 Apr 15;28(8):1277-82. doi: 10.1016/0006-2952(79)90424-6. Biochem Pharmacol. 1979. PMID: 36095 Review. No abstract available.
-
The pharmacology of prazosin, a novel antihypertensive agent.Life Sci. 1980 Oct 27;27(17):1525-40. doi: 10.1016/0024-3205(80)90561-5. Life Sci. 1980. PMID: 6255278 Review. No abstract available.
Cited by
-
5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by alpha-adrenoceptor antagonists in rats.Br J Pharmacol. 1986 Oct;89(2):293-8. doi: 10.1111/j.1476-5381.1986.tb10259.x. Br J Pharmacol. 1986. PMID: 2877697 Free PMC article.
-
Typical and atypical neuroleptics are potent antagonists at alpha 1-adrenoceptors of the dorsal lateral geniculate nucleus. An electrophysiological study.Naunyn Schmiedebergs Arch Pharmacol. 1982 Oct;321(1):32-7. doi: 10.1007/BF00586345. Naunyn Schmiedebergs Arch Pharmacol. 1982. PMID: 6128681
-
Hypotensive and alpha-adrenergic activities of 2-(2,3,6-trichlorophenylimino) and 2-(2,3-dichloro-6-methylphenylimino) imidazolidine, two potent derivatives of clonidine.Br J Pharmacol. 1983 Mar;78(3):479-87. doi: 10.1111/j.1476-5381.1983.tb08808.x. Br J Pharmacol. 1983. PMID: 6132639 Free PMC article.
-
Characterization of a novel 5-HT4 receptor antagonist of the azabicycloalkyl benzimidazolone class: DAU 6285.Naunyn Schmiedebergs Arch Pharmacol. 1992 Mar;345(3):264-9. doi: 10.1007/BF00168685. Naunyn Schmiedebergs Arch Pharmacol. 1992. PMID: 1320204
-
Role of central alpha-1 adrenoceptors in canine narcolepsy.J Clin Invest. 1988 Sep;82(3):885-94. doi: 10.1172/JCI113694. J Clin Invest. 1988. PMID: 2843574 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information
