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Comment
. 2023 Nov;72(11):2010-2012.
doi: 10.1136/gutjnl-2023-329801. Epub 2023 Apr 25.

Defective microbial sensing and clearance in perianal Crohn's disease: a role for complement factor B

Arya Ghate  1 , Holm H Uhlig  2   3   4
Affiliations
Comment

Defective microbial sensing and clearance in perianal Crohn's disease: a role for complement factor B

Arya Ghate et al. Gut. 2023 Nov.
No abstract available

Keywords: gastrointestinal fistulae; genetics; inflammatory bowel disease.

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Conflict of interest statement

Competing interests: None declared.

Comment on

  • Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
    Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M; International IBD Genetics Consortium; Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS. Akhlaghpour M, et al. Gut. 2023 Nov;72(11):2068-2080. doi: 10.1136/gutjnl-2023-329689. Epub 2023 Apr 20. Gut. 2023. PMID: 37080587 Free PMC article.

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